UniProt Accession

 CD1A_HUMAN; P06126; D3DVD7; Q13962; Q5TDJ8; Q9UMM4; Q9Y5M5 

Genbank Protein ID

 M28825; M22167; M22080; M22163; M22164; M22165; M22166; AK312945; AL121986; CH471121; CH471121; AF142665; M27735; X04450; M14663 

Genbank Nucleotide ID

 AAA51931.1; AAA51932.1; AAA51932.1; AAA51932.1; AAA51932.1; AAA51932.1; AAA51932.1; BAG35786.1; CAI10848.1; EAW52843.1; EAW52844.1; AAD37578.1; AAA51933.1; CAA28049.1; AAA51934.1 

Protein Name

 T-cell surface glycoprotein CD1a 

Protein Synonyms/Alias

 T-cell surface antigen T6/Leu-6; hTa1 thymocyte antigen; CD1a 

Gene Name

 CD1A 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
81	NFSNEEWKELETLFR	ubiquitination	[1]
163	NMAKHFCKVLNQNQH	ubiquitination	[1]
195	LGLLDAGKAHLQRQV	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. 

Sequence Annotation

 DOMAIN 184 291 Ig-like.
 REGION 90 94 Glycolipid binding.
 BINDING 171 171 Glycolipid.
 CARBOHYD 37 37 N-linked (GlcNAc...).
 CARBOHYD 60 60 N-linked (GlcNAc...) (Potential).
 CARBOHYD 74 74 N-linked (GlcNAc...).
 CARBOHYD 145 145 N-linked (GlcNAc...).
 DISULFID 119 183 By similarity.
 DISULFID 223 278  

Keyword

 3D-structure; Adaptive immunity; Cell membrane; Complete proteome; Disulfide bond; Endosome; Glycoprotein; Immunity; Immunoglobulin domain; Membrane; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 327 AA 

Protein Sequence

Gene Ontology

 GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
 GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.
 GO:0042612; C:MHC class I protein complex; IEA:InterPro.
 GO:0019882; P:antigen processing and presentation; IEA:InterPro.
 GO:0006955; P:immune response; NAS:UniProtKB. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003597; Ig_C1-set.
 IPR011161; MHC_I-like_Ag-recog.
 IPR011162; MHC_I/II-like_Ag-recog.
 IPR001039; MHC_I_a_a1/a2. 

Pfam

 PF07654; C1-set
 PF00129; MHC_I 

SMART

 SM00407; IGc1 

PROSITE

 PS50835; IG_LIKE 

PRINTS