CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004044
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ski-like protein 
Protein Synonyms/Alias
 Ski-related oncogene; Ski-related protein 
Gene Name
 SKIL 
Gene Synonyms/Alias
 SNO 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
50INKVPTVKKEHLDDYsumoylation[1, 2]
249NGSVLPAKSSLAQLKubiquitination[3]
383QSWYPVIKQEGDHVSsumoylation[1, 2]
423TSAVSQSKELTKTEAubiquitination[3]
551KLNLILQKKQQLQMEubiquitination[3]
Reference
 [1] Sumoylated SnoN represses transcription in a promoter-specific manner.
 Hsu YH, Sarker KP, Pot I, Chan A, Netherton SJ, Bonni S.
 J Biol Chem. 2006 Nov 3;281(44):33008-18. [PMID: 16966324]
 [2] Transforming growth factor-beta-independent regulation of myogenesis by SnoN sumoylation.
 Wrighton KH, Liang M, Bryan B, Luo K, Liu M, Feng XH, Lin X.
 J Biol Chem. 2007 Mar 2;282(9):6517-24. [PMID: 17202138]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 May have regulatory role in cell division or differentiation in response to extracellular signals. 
Sequence Annotation
  
Keyword
 3D-structure; Alternative splicing; Coiled coil; Complete proteome; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 684 AA 
Protein Sequence
MENLQTNFSL VQGSTKKLNG MGDDGSPPAK KMITDIHANG KTINKVPTVK KEHLDDYGEA 60
PVETDGEHVK RTCTSVPETL HLNPSLKHTL AQFHLSSQSS LGGPAAFSAR HSQESMSPTV 120
FLPLPSPQVL PGPLLIPSDS STELTQTVLE GESISCFQVG GEKRLCLPQV LNSVLREFTL 180
QQINTVCDEL YIYCSRCTSD QLHILKVLGI LPFNAPSCGL ITLTDAQRLC NALLRPRTFP 240
QNGSVLPAKS SLAQLKETGS AFEVEHECLG KCQGLFAPQF YVQPDAPCIQ CLECCGMFAP 300
QTFVMHSHRS PDKRTCHWGF ESAKWHCYLH VNQKYLGTPE EKKLKIILEE MKEKFSMRSG 360
KRNQSKTDAP SGMELQSWYP VIKQEGDHVS QTHSFLHPSY YLYMCDKVVA PNVSLTSAVS 420
QSKELTKTEA SKSISRQSEK AHSSGKLQKT VSYPDVSLEE QEKMDLKTSR ELCSRLDASI 480
SNNSTSKRKS ESATCNLVRD INKVGIGLVA AASSPLLVKD VICEDDKGKI MEEVMRTYLK 540
QQEKLNLILQ KKQQLQMEVK MLSSSKSMKE LTEEQQNLQK ELESLQNEHA QRMEEFYVEQ 600
KDLEKKLEQI MKQKCTCDSN LEKDKEAEYA GQLAELRQRL DHAEADRQEL QDELRQEREA 660
RQKLEMMIKE LKLQILKSSK TAKE 684 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0016605; C:PML body; IDA:UniProtKB.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0032403; F:protein complex binding; IDA:UniProtKB.
 GO:0003714; F:transcription corepressor activity; IDA:UniProtKB.
 GO:0001825; P:blastocyst formation; IEA:Compara.
 GO:0007050; P:cell cycle arrest; IEA:Compara.
 GO:0070306; P:lens fiber cell differentiation; IEA:Compara.
 GO:0002260; P:lymphocyte homeostasis; IEA:Compara.
 GO:0045596; P:negative regulation of cell differentiation; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IDA:UniProtKB.
 GO:0050772; P:positive regulation of axonogenesis; IMP:UniProtKB.
 GO:0070208; P:protein heterotrimerization; IDA:UniProtKB.
 GO:0070207; P:protein homotrimerization; IDA:UniProtKB.
 GO:0042981; P:regulation of apoptotic process; IBA:RefGenome.
 GO:0046677; P:response to antibiotic; IEP:UniProtKB.
 GO:0070848; P:response to growth factor stimulus; IDA:UniProtKB.
 GO:0007519; P:skeletal muscle tissue development; IDA:UniProtKB.
 GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:Reactome.
 GO:0007179; P:transforming growth factor beta receptor signaling pathway; TAS:Reactome. 
Interpro
 IPR014890; c-SKI_SMAD4-bd_dom.
 IPR009061; DNA-bd_dom_put.
 IPR010919; SAND_dom-like.
 IPR003380; Transform_Ski.
 IPR023216; Tscrpt_reg_SKI_SnoN. 
Pfam
 PF08782; c-SKI_SMAD_bind
 PF02437; Ski_Sno 
SMART
 SM01046; c-SKI_SMAD_bind 
PROSITE
  
PRINTS