| Tag | Content |
|---|
| CPLM ID | CPLM-000695 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | WD repeat-containing protein 62 |
Protein Synonyms/Alias | |
Gene Name | WDR62 |
Gene Synonyms/Alias | C19orf14 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 102 | ILDPKENKQQHIFNT | ubiquitination | [1] | | 112 | HIFNTARKSLSALAF | ubiquitination | [1] | | 145 | RIWDVEEKNQVAEML | ubiquitination | [1] | | 452 | SPDSHWQKNIFSNTL | ubiquitination | [1] | | 492 | NGTPMDVKAGVRVMQ | ubiquitination | [1] | | 587 | SSSITAIKFAGNRDI | ubiquitination | [1] | | 603 | MISCGADKSIYFRSA | ubiquitination | [1] | | 832 | RCLLTNGKLPLWAKR | ubiquitination | [1] | | 838 | GKLPLWAKRLLGDDD | ubiquitination | [1] | | 855 | DGLAFHAKRSYQPHG | ubiquitination | [1] | | 961 | TDSQYCRKEVEAGPG | ubiquitination | [1] | | 1127 | RATQCLVKSPEVKLM | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Required for cerebral cortical development. Plays a role in neuronal proliferation and migration. |
Sequence Annotation | REPEAT 109 150 WD 1.
REPEAT 153 194 WD 2.
REPEAT 196 234 WD 3.
REPEAT 291 330 WD 4.
REPEAT 357 396 WD 5.
REPEAT 402 450 WD 6.
REPEAT 490 529 WD 7.
REPEAT 532 574 WD 8.
REPEAT 578 618 WD 9.
REPEAT 626 665 WD 10.
REPEAT 671 713 WD 11.
REPEAT 714 752 WD 12.
REPEAT 803 846 WD 13.
REPEAT 1132 1173 WD 14.
REPEAT 1255 1293 WD 15.
MOD_RES 2 2 N-acetylalanine.
MOD_RES 46 46 Phosphothreonine.
MOD_RES 49 49 Phosphoserine.
MOD_RES 50 50 Phosphothreonine.
MOD_RES 52 52 Phosphoserine.
MOD_RES 501 501 Phosphoserine.
MOD_RES 1053 1053 Phosphothreonine.
MOD_RES 1093 1093 Phosphoserine.
MOD_RES 1101 1101 Phosphoserine.
MOD_RES 1123 1123 Phosphoserine.
MOD_RES 1228 1228 Phosphoserine.
MOD_RES 1248 1248 Phosphoserine.
MOD_RES 1249 1249 Phosphoserine.
MOD_RES 1268 1268 Phosphothreonine. |
Keyword | Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Disease mutation; Mental retardation; Neurogenesis; Nucleus; Phosphoprotein; Polymorphism; Primary microcephaly; Reference proteome; Repeat; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1518 AA |
Protein Sequence | MAAVGSGGYA RNDAGEKLPS VMAGVPARRG QSSPPPAPPI CLRRRTRLST ASEETVQNRV 60
SLEKVLGITA QNSSGLTCDP GTGHVAYLAG CVVVILDPKE NKQQHIFNTA RKSLSALAFS 120
PDGKYIVTGE NGHRPAVRIW DVEEKNQVAE MLGHKYGVAC VAFSPNMKHI VSMGYQHDMV 180
LNVWDWKKDI VVASNKVSCR VIALSFSEDS SYFVTVGNRH VRFWFLEVST ETKVTSTVPL 240
VGRSGILGEL HNNIFCGVAC GRGRMAGSTF CVSYSGLLCQ FNEKRVLEKW INLKVSLSSC 300
LCVSQELIFC GCTDGIVRIF QAHSLHYLAN LPKPHYLGVD VAQGLEPSFL FHRKAEAVYP 360
DTVALTFDPI HQWLSCVYKD HSIYIWDVKD INRVGKVWSE LFHSSYVWNV EVYPEFEDQR 420
ACLPSGSFLT CSSDNTIRFW NLDSSPDSHW QKNIFSNTLL KVVYVENDIQ HLQDMSHFPD 480
RGSENGTPMD VKAGVRVMQV SPDGQHLASG DRSGNLRIHE LHFMDELVKV EAHDAEVLCL 540
EYSKPETGLT LLASASRDRL IHVLNVEKNY NLEQTLDDHS SSITAIKFAG NRDIQMISCG 600
ADKSIYFRSA QQGSDGLHFV RTHHVAEKTT LYDMDIDITQ KYVAVACQDR NVRVYNTVNG 660
KQKKCYKGSQ GDEGSLLKVH VDPSGTFLAT SCSDKSISVI DFYSGECIAK MFGHSEIITS 720
MKFTYDCHHL ITVSGDSCVF IWHLGPEITN CMKQHLLEID HRQQQQHTND KKRSGHPRQD 780
TYVSTPSEIH SLSPGEQTED DLEEECEPEE MLKTPSKDSL DPDPRCLLTN GKLPLWAKRL 840
LGDDDVADGL AFHAKRSYQP HGRWAERAGQ EPLKTILDAQ DLDCYFTPMK PESLENSILD 900
SLEPQSLASL LSESESPQEA GRGHPSFLPQ QKESSEASEL ILYSLEAEVT VTGTDSQYCR 960
KEVEAGPGDQ QGDSYLRVSS DSPKDQSPPE DSGESEADLE CSFAAIHSPA PPPDPAPRFA 1020
TSLPHFPGCA GPTEDELSLP EGPSVPSSSL PQTPEQEKFL RHHFETLTES PCRELFPAAL 1080
GDVEASEAED HFFNPRLSIS TQFLSSLQKA SRFTHTFPPR ATQCLVKSPE VKLMDRGGSQ 1140
PRAGTGYASP DRTHVLAAGK AEETLEAWRP PPPCLTSLAS CVPASSVLPT DRNLPTPTSA 1200
PTPGLAQGVH APSTCSYMEA TASSRARISR SISLGDSEGP IVATLAQPLR RPSSVGELAS 1260
LGQELQAITT ATTPSLDSEG QEPALRSWGN HEARANLRLT LSSACDGLLQ PPVDTQPGVT 1320
VPAVSFPAPS PVEESALRLH GSAFRPSLPA PESPGLPAHP SNPQLPEARP GIPGGTASLL 1380
EPTSGALGLL QGSPARWSEP WVPVEALPPS PLELSRVGNI LHRLQTTFQE ALDLYRVLVS 1440
SGQVDTGQQQ ARTELVSTFL WIHSQLEAEC LVGTSVAPAQ ALPSPGPPSP PTLYPLASPD 1500
LQALLEHYSE LLVQAVRRKA RGH 1523 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |