CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043531
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Cytoplasmic tRNA 2-thiolation protein 2 
Protein Synonyms/Alias
  
Gene Name
 CTU2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
309SVRTLTAKEELLQTLubiquitination[1, 2, 3]
332ARAHGYSKVMTGDSCubiquitination[2, 4, 5]
384PMRDHTLKEVAFYNRubiquitination[1, 2, 4]
406FTPAVDTKAPEKASIubiquitination[1, 3]
444RTSEKLVKGPRDGPAubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Cytoplasm; Reference proteome; tRNA processing. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 586 AA 
Protein Sequence
MCQVGEDYGE PAPEEPPPAP RPSREQKCVK CKEAQPVVVI RAGDAFCRDC FKAFYVHKFR 60
AMLGKNRLIF PGEKVLLAWS GGPSSSSMVW QVLEGLSQDS AKRLRFVAGV IFVDERTPGV 120
LTVALRSAAR EKPLPKGKWP TPHSSARKHR PAERGLEGFS QVEVALQPAL PGSSLSPDSF 180
CLGFSEGAAC GQSLEERSKT LAEVKPILQA TGFPWHVVAL EEVFSLPPSV LWCSAQELVG 240
SEGAYKAAVD SFLQQQHVLG AGGGPGPTQG EEQPPQPPLD PQNLARPPAP AQTEALSQLF 300
CSVRTLTAKE ELLQTLRTHL ILHMARAHGY SKVMTGDSCT RLAIKLMTNL ALGRGAFLAW 360
DTGFSDERHG DVVVVRPMRD HTLKEVAFYN RLFSVPSVFT PAVDTKAPEK ASIHRLMEAF 420
ILRLQTQFPS TVSTVYRTSE KLVKGPRDGP AAGDSGPRCL LCMCALDVDA ADSATAFGAQ 480
TSSRLSQMQS PIPLTETRTP PGPCCSPGVG WAQRCGQGAC RREDPQACIE EQLCYSCRVN 540
MKDLPSLDPL PPYILAEAQL RTQRAWGLQE IRDCLIEDSD DEAGQS 586 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0008033; P:tRNA processing; IEA:UniProtKB-KW. 
Interpro
 IPR019407; Thiouridylase_cyt_su2. 
Pfam
 PF10288; DUF2392 
SMART
  
PROSITE
  
PRINTS