UniProt Accession

 GATM_HUMAN; P50440; B4DH99; B4DPI3; Q53EQ4 

Genbank Protein ID

 S68805; X86401; AK294995; AK298350; AK223585; AC025580; BC004141 

Genbank Nucleotide ID

 AAB29892.1; CAA60153.1; BAG58060.1; BAG60595.1; BAD97305.1; AAH04141.1 

Protein Name

 Glycine amidinotransferase, mitochondrial 

Protein Synonyms/Alias

 L-arginine:glycine amidinotransferase; Transamidinase 

Gene Name

 GATM 

Gene Synonyms/Alias

 AGAT 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
385	PIQKMFEKLGITTIK	acetylation	[1, 2]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. May be involved in the response to heart failure by elevating local creatine synthesis. 

Sequence Annotation

 ACT_SITE 254 254
 ACT_SITE 303 303
 ACT_SITE 407 407 Amidino-cysteine intermediate.
 MOD_RES 385 385 N6-acetyllysine.
 MOD_RES 417 417 Phosphothreonine (By similarity).  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Membrane; Mitochondrion; Mitochondrion inner membrane; Phosphoprotein; Polymorphism; Reference proteome; Transferase; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 423 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
 GO:0005758; C:mitochondrial intermembrane space; IDA:MGI.
 GO:0015068; F:glycine amidinotransferase activity; IDA:MGI.
 GO:0016813; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines; IEA:InterPro.
 GO:0034641; P:cellular nitrogen compound metabolic process; TAS:Reactome.
 GO:0006601; P:creatine biosynthetic process; IDA:MGI.
 GO:0009790; P:embryo development; IEA:Compara.
 GO:0046689; P:response to mercury ion; IEA:Compara.
 GO:0007584; P:response to nutrient; IEA:Compara.
 GO:0006979; P:response to oxidative stress; IEA:Compara.
 GO:0043434; P:response to peptide hormone stimulus; IEA:Compara.
 GO:0042246; P:tissue regeneration; IEA:Compara. 

Interpro

 IPR003198; Amidino_trans. 

Pfam

 PF02274; Amidinotransf 

SMART

  

PROSITE

  

PRINTS