CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035652
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 DNA fragmentation factor subunit beta 
Protein Synonyms/Alias
  
Gene Name
 Cad 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
747IPRWDLSKFLRVSTKacetylation[1]
1431VPLIIDIKCTKLFVEacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2224 AA 
Protein Sequence
MAALVLEDGS VLQGRPFGAA VSTAGEVVFQ TGMVGYPEAL TDPSYKAQIL VLTYPLIGNY 60
GIPSDEEDEF GLSKWFESSE IHVAGLVVGE CCPTPSHWSA TCTLHEWLQQ HGIPGLQGVD 120
TRELTKKLRE QGSLLGKLVQ KGTEPSALPF VDPNARPLAP EVSIKTPRVF NAGGAPRIFA 180
VDCGLKYNQI RCLCQLGAEV TVVPWNHELD SRKYDGLFLS NGPGDPASYP GVVSTLNRVL 240
SEPNPRPVFG ICLGHQLLAL AIGAKTYKMR YGNRGHNQPC LLVGTGRCFL TSQNHGFAVD 300
ADSLPAGWAP LFTNANDCSN EGIVHDNLPF FSVQFHPEHR AGPSDMELLF DVFLETVRDT 360
VAGNAEGRTV RERLAQRLCP PELPIPGSGL PPPRKVLILG SGGLSIGQAG EFDYSGSQAI 420
KALKEENIQT LLINPNIATV QTSQGLADKV YFLPITPHYV TQVIRNERPD GILLTFGGQT 480
ALNCGVELTK AGVLARYGVR VLGTPVETIE LTEDRRAFAA RMAEIGEHVA PSEAANSLEQ 540
AQAAAERLGY PVLVRAAFAL GGLGSGFAST KEELSALVAP AFAHTSQVLI DKSLKGWKEI 600
EYEVVRDAYG NCVTVCNMEN LDPLGIHTGE SIVVAPSQTL NDREYQLLRR TAIKVTQHLG 660
IVGECNVQYA LNPESEQYYI IEVNARLSRS SALASKATGY PLAYVAAKLA LGIPLPELRN 720
SVTGGTAAFE PSLDYCVVKI PRWDLSKFLR VSTKIGSCMK SVGEVMGIGR SFEEAFQKAL 780
RMVDENCVGF DHTVKPVSDV ELETPTDKRI FVVAAALWAG YSVERLYELT RIDCWFLHRM 840
KRIVTHAKLL EQHRGRPLPQ DLLHQAKCLG FSDKQIALAV LSTELVVRKL RQELGICPAV 900
KQIDTVAAEW PAQTNYLYLT YWGNTHDLDF RTPHVLVLGS GVYRIGSSVE FDWCAVGCIQ 960
QLRKMGYKTI MVNYNPETVS TDYDMCDRLY FDEISFEVVM DIYELENPEG VILSMGGQLP 1020
NNMAMALHRQ QCRVLGTSPE AIDSAENRFK FSRLLDTIGI SQPQWRELSD LESARQFCQT 1080
VGYPCVVRPS YVLSGAAMNV AYTDGDLERF LSSAAAVSKE HPVVISKFIQ EAKEIDVDAV 1140
ACDGIVSAIA ISEHVENAGV HSGDATLVTP PQDITPKTLE RIKAIVHAVG QELQVTGPFN 1200
LQLIAKDDQL KVIECNVRVS RSFPFVSKTL GVDLVALATR IIMGEKVESV GLMTGSGVVG 1260
VKVPQFSFSR LAGADVVLGV EMTSTGEVAG FGESRCEAYL KAMLSTGFKI PKKNILLTIG 1320
SYKNKSELLP TVRLLESLGY SLYASLGTAD FYTEHGVKVT AVDWHFEEAV DGECPPQRSI 1380
LDQLAENHFE LVINLSMRGA GGRRLSSFVT KGYRTRRLAA DFSVPLIIDI KCTKLFVEAL 1440
GQIGPAPPLK VHVDCMTSQK LVRLPGLIDV HVHLREPGGT HKEDFASGTA AALAGGVTMV 1500
CAMPNTRPPI IDAPALALAQ KLAEAGARCD FTLFLGASSE NAGTLGAVAG SAAGLKLYLN 1560
ETFSELRLDS VAQWMEHFET WPSHLPIVAH AERQSVAAVL MAQLTRRSVH ICHVARKEEI 1620
LLIKTAKAQG LPVTCEVAPH HLFLNREDLE RLGPGKGEVR PELGSREDME ALWENMAVID 1680
CFASDHAPHT LEEKCGPKPP PGFPGLETML PLLLTAVSEG RLSLDDLLQR LHHNPRRIFH 1740
LPLQEDTYVE VDLEHEWTVP SHMPFSKAHW TPFEGQKVKG TVRRVVLRGE VAYIDGQVLV 1800
PPGYGQDVRK WPQGAVPQPP PPTPTTTEIT TTPERPRRVI PGLPDGRFHL PPRIHRASDP 1860
GLPAEEPKEK PPRKVAESEL IGTPDGPCYP VPPVPRQASP QNLGSSGLLH PQMSPLLHSL 1920
VGQHILSVKQ FTKDQMSHLF NVAHTLRMMV QKERSLDILK GKVMASMFYE VSTRTSSSFA 1980
AAMARLGGAV LSFSEATSSV QKGESLADSV QTMSCYADVV VLRHPQPGAV ELAAKHCRRP 2040
VINAGDGVGE HPTQALLDIF TIREELGTVN GMTITMVGDL KHGRTVHSLA CLLTQYRVSL 2100
RYVAPPSLRM PSSVWDFVAS RGTKQEEFES IEEALPDTDV LYMTRIQKER FGSSQEYEAC 2160
FGQFILTPHI MTRAKKKMVV MHPMPRVNEI SVEVDSDPRA AYFRQAENGM YIRMALLATV 2220
LGRF 2224 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0043025; C:neuronal cell body; IDA:RGD.
 GO:0016363; C:nuclear matrix; IEA:Compara.
 GO:0043234; C:protein complex; IDA:RGD.
 GO:0043195; C:terminal bouton; IDA:RGD.
 GO:0016597; F:amino acid binding; IEA:InterPro.
 GO:0004070; F:aspartate carbamoyltransferase activity; IDA:RGD.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004088; F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; IDA:RGD.
 GO:0004151; F:dihydroorotase activity; IDA:RGD.
 GO:0042802; F:identical protein binding; IDA:RGD.
 GO:0046872; F:metal ion binding; IEA:InterPro.
 GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IDA:RGD.
 GO:0070409; P:carbamoyl phosphate biosynthetic process; IEA:InterPro.
 GO:0035690; P:cellular response to drug; IEP:RGD.
 GO:0071364; P:cellular response to epidermal growth factor stimulus; IEP:RGD.
 GO:0017144; P:drug metabolic process; IMP:RGD.
 GO:0009790; P:embryo development; IEP:RGD.
 GO:0007565; P:female pregnancy; IEP:RGD.
 GO:0006543; P:glutamine catabolic process; IEA:InterPro.
 GO:0006541; P:glutamine metabolic process; IEP:RGD.
 GO:0007595; P:lactation; IEP:RGD.
 GO:0031100; P:organ regeneration; IEP:RGD.
 GO:0014075; P:response to amine stimulus; IEP:RGD.
 GO:0031000; P:response to caffeine; IEP:RGD.
 GO:0051414; P:response to cortisol stimulus; IEP:RGD.
 GO:0033574; P:response to testosterone stimulus; IEP:RGD.
 GO:0006228; P:UTP biosynthetic process; IDA:RGD. 
Interpro
 IPR006132; Asp/Orn_carbamoyltranf_P-bd.
 IPR006130; Asp/Orn_carbamoylTrfase.
 IPR002082; Asp_carbamoyltransf.
 IPR006131; Asp_carbamoyltransf_Asp/Orn-bd.
 IPR011761; ATP-grasp.
 IPR013815; ATP_grasp_subdomain_1.
 IPR013816; ATP_grasp_subdomain_2.
 IPR006275; CarbamoylP_synth_lsu.
 IPR005481; CarbamoylP_synth_lsu_N.
 IPR005480; CarbamoylP_synth_lsu_oligo.
 IPR006274; CarbamoylP_synth_ssu.
 IPR002474; CarbamoylP_synth_ssu_N.
 IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
 IPR005483; CbamoylP_synth_lsu_CPSase_dom.
 IPR002195; Dihydroorotase_CS.
 IPR017926; GATASE.
 IPR011059; Metal-dep_hydrolase_composite.
 IPR011607; MGS-like_dom.
 IPR016185; PreATP-grasp_dom. 
Pfam
 PF00289; CPSase_L_chain
 PF02786; CPSase_L_D2
 PF02787; CPSase_L_D3
 PF00988; CPSase_sm_chain
 PF00117; GATase
 PF02142; MGS
 PF00185; OTCace
 PF02729; OTCace_N 
SMART
 SM01096; CPSase_L_D3
 SM01097; CPSase_sm_chain
 SM00851; MGS 
PROSITE
 PS50975; ATP_GRASP
 PS00097; CARBAMOYLTRANSFERASE
 PS00866; CPSASE_1
 PS00867; CPSASE_2
 PS00482; DIHYDROOROTASE_1
 PS00483; DIHYDROOROTASE_2
 PS51273; GATASE_TYPE_1 
PRINTS
 PR00100; AOTCASE.
 PR00101; ATCASE.
 PR00098; CPSASE.