CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005712
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Retinoic acid receptor RXR-alpha 
Protein Synonyms/Alias
 Nuclear receptor subfamily 2 group B member 1; Retinoid X receptor alpha 
Gene Name
 Rxra 
Gene Synonyms/Alias
 Nr2b1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
4****MDTKHFLPLDFubiquitination[1]
386VLFNPDSKGLSNPAEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes. 
Sequence Annotation
 DNA_BIND 140 205 Nuclear receptor.
 ZN_FING 140 160 NR C4-type.
 ZN_FING 176 200 NR C4-type.
 REGION 1 139 Modulating domain (By similarity).
 REGION 206 229 Hinge.
 REGION 230 467 Ligand-binding domain.
 MOD_RES 22 22 Phosphoserine.
 MOD_RES 28 28 Phosphoserine (By similarity).
 MOD_RES 61 61 Phosphoserine; by MAPK8 and MAPK9.
 MOD_RES 75 75 Phosphoserine; by MAPK8 and MAPK9.
 MOD_RES 87 87 Phosphothreonine; by MAPK8 and MAPK9.
 MOD_RES 265 265 Phosphoserine; by MAPK8 and MAPK9.
 CROSSLNK 113 113 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 3D-structure; Complete proteome; Direct protein sequencing; DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Phosphoprotein; Receptor; Reference proteome; Transcription; Transcription regulation; Ubl conjugation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 467 AA 
Protein Sequence
MDTKHFLPLD FSTQVNSSSL NSPTGRGSMA VPSLHPSLGP GIGSPLGSPG QLHSPISTLS 60
SPINGMGPPF SVISSPMGPH SMSVPTTPTL GFGTGSPQLN SPMNPVSSTE DIKPPLGLNG 120
VLKVPAHPSG NMASFTKHIC AICGDRSSGK HYGVYSCEGC KGFFKRTVRK DLTYTCRDNK 180
DCLIDKRQRN RCQYCRYQKC LAMGMKREAV QEERQRGKDR NENEVESTSS ANEDMPVEKI 240
LEAELAVEPK TETYVEANMG LNPSSPNDPV TNICQAADKQ LFTLVEWAKR IPHFSELPLD 300
DQVILLRAGW NELLIASFSH RSIAVKDGIL LATGLHVHRN SAHSAGVGAI FDRVLTELVS 360
KMRDMQMDKT ELGCLRAIVL FNPDSKGLSN PAEVEALREK VYASLEAYCK HKYPEQPGRF 420
AKLLLRLPAL RSIGLKCLEH LFFFKLIGDT PIDTFLMEML EAPHQAT 467 
Gene Ontology
 GO:0000790; C:nuclear chromatin; IEA:Compara.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0004886; F:9-cis retinoic acid receptor activity; IDA:MGI.
 GO:0031490; F:chromatin DNA binding; IDA:MGI.
 GO:0044323; F:retinoic acid-responsive element binding; IEA:Compara.
 GO:0043565; F:sequence-specific DNA binding; IGI:MGI.
 GO:0003707; F:steroid hormone receptor activity; IEA:InterPro.
 GO:0070644; F:vitamin D response element binding; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0060978; P:angiogenesis involved in coronary vascular morphogenesis; TAS:DFLAT.
 GO:0060038; P:cardiac muscle cell proliferation; TAS:DFLAT.
 GO:0007566; P:embryo implantation; IGI:MGI.
 GO:0001701; P:in utero embryonic development; IGI:MGI.
 GO:0001893; P:maternal placenta development; IGI:MGI.
 GO:0060485; P:mesenchyme development; TAS:DFLAT.
 GO:0010629; P:negative regulation of gene expression; TAS:DFLAT.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0035357; P:peroxisome proliferator activated receptor signaling pathway; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0060687; P:regulation of branching involved in prostate gland morphogenesis; IMP:MGI.
 GO:0032526; P:response to retinoic acid; IEA:Compara.
 GO:0060528; P:secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development; IMP:MGI.
 GO:0055012; P:ventricular cardiac muscle cell differentiation; IMP:MGI.
 GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IMP:MGI.
 GO:0019048; P:virus-host interaction; IEA:Compara.
 GO:0061032; P:visceral serous pericardium development; TAS:DFLAT. 
Interpro
 IPR021780; Nuc_recep-AF1.
 IPR008946; Nucl_hormone_rcpt_ligand-bd.
 IPR000536; Nucl_hrmn_rcpt_lig-bd_core.
 IPR000003; Retinoid-X_rcpt/HNF4.
 IPR001723; Str_hrmn_rcpt.
 IPR001628; Znf_hrmn_rcpt.
 IPR013088; Znf_NHR/GATA. 
Pfam
 PF00104; Hormone_recep
 PF11825; Nuc_recep-AF1
 PF00105; zf-C4 
SMART
 SM00430; HOLI
 SM00399; ZnF_C4 
PROSITE
 PS00031; NUCLEAR_REC_DBD_1
 PS51030; NUCLEAR_REC_DBD_2 
PRINTS
 PR00545; RETINOIDXR.
 PR00398; STRDHORMONER.
 PR00047; STROIDFINGER.