CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016103
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Lethal(2) giant larvae protein homolog 1 
Protein Synonyms/Alias
 LLGL; Mgl-1; Mlgl 
Gene Name
 Llgl1 
Gene Synonyms/Alias
 Llglh 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
905VHYSCIRKEDISGIAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. 
Sequence Annotation
 REPEAT 38 71 WD 1.
 REPEAT 78 119 WD 2.
 REPEAT 139 175 WD 3.
 REPEAT 199 233 WD 4.
 REPEAT 239 271 WD 5.
 REPEAT 289 331 WD 6.
 REPEAT 339 373 WD 7.
 REPEAT 395 473 WD 8.
 REPEAT 517 592 WD 9.
 REPEAT 601 662 WD 10.
 REPEAT 722 782 WD 11.
 REPEAT 791 843 WD 12.
 REPEAT 848 901 WD 13.
 REPEAT 915 938 WD 14.
 MOD_RES 662 662 Phosphoserine (By similarity).
 MOD_RES 957 957 Phosphothreonine.
 MOD_RES 964 964 Phosphoserine.  
Keyword
 Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Endosome; Exocytosis; Golgi apparatus; Membrane; Phosphoprotein; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1036 AA 
Protein Sequence
MMKFRFRRQG ADPQREKLKQ ELFAFHKTVE HGFPNQPSAL AFDPELRIMA IGTRSGAVKI 60
YGAPGVEFTG LHRDAATVTQ MHFLPGQGRL LTLLDDSSLH LWEIIHHNGC AHLEEGLSFH 120
PPSRPSFDNA SFPASLTRVT VVLLVAGNTA ALGTESGSIF FLDVATLALL EGQTLSPDVV 180
LRSVPDDYRC GKALGPVESL QGHLQDPSKI LIGYSRGLLV IWSQATQSVD NVFLGNQQLE 240
SLCWGRDGSS IISSHSDGSY AIWSTDTGSP PTLQPTVVTT PYGPFPCKAI NKILWRSCES 300
GDHFIIFSGG MPRASYGDRH CVSVLRAETL VTLDFTSRVI DFFTVHSTQP EDECDNPQAL 360
AVLLEEELVV LDLQTPGWPA VPAPYLAPLH SSAITCSAHV ANVPSKLWAR IVSAGEQQSP 420
QPASSALSWP ITGGRNLAQE PSQRGLLLTG HEDGTVRFWD ASGVALRPLY KLSTAGLFQT 480
DCEHADSLAQ AVEDDWPPFR KVGCFDPYSD DPRLGIQKVA LCKYTAQMVV AGTAGQVLVL 540
ELSEVPAEHA VSVANVDLLQ DREGFTWKGH ERLNPHTGLL PWPAGFQPRM LIQCLPPAAV 600
TAVTLHAEWS LVAFGTSHGF GLFDYQRKSP VLARCTLHPN DSLAMEGPLS RVKSLKKSLR 660
QSFRRIRKSR VSGKKRTPAA SSKLQEANAQ LAEQTCPHDL EMTPVQRRIE PRSADDSLSG 720
VVRCLYFADT FLRDATHHGP TMWAGTNSGS VFAYALEVPA ATAGGEKRPE QAVEAVLGKE 780
VQLMHRAPVV AIAVLDGRGR PLPEPYEASR DLAQAPDMQG GHAVLIASEE QFKVFTLPKV 840
SAKTKFKLTA HEGCRVRKVA LATFASVMSE DYAETCLACL TNLGDVHVFS VPGLRPQVHY 900
SCIRKEDISG IASCVFTRHG QGFYLISPSE FERFSLSARN ITEPLCSLDI SWPQNATQPR 960
LQESPKLSQA NGTRDIILAP ESCEGSPSSA HSKRADTMEP PEAALSPVSI DSAASGDTML 1020
DTTGDVTVEY VKDFLG 1036 
Gene Ontology
 GO:0030424; C:axon; IEA:UniProtKB-SubCell.
 GO:0030864; C:cortical actin cytoskeleton; IEA:Compara.
 GO:0005856; C:cytoskeleton; IDA:UniProtKB.
 GO:0031901; C:early endosome membrane; ISS:UniProtKB.
 GO:0000137; C:Golgi cis cisterna; ISS:UniProtKB.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0035748; C:myelin sheath abaxonal region; IDA:BHF-UCL.
 GO:0032588; C:trans-Golgi network membrane; ISS:UniProtKB.
 GO:0005097; F:Rab GTPase activator activity; ISS:UniProtKB.
 GO:0007409; P:axonogenesis; ISS:UniProtKB.
 GO:0007420; P:brain development; TAS:UniProtKB.
 GO:0030866; P:cortical actin cytoskeleton organization; IEA:Compara.
 GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
 GO:0006893; P:Golgi to plasma membrane transport; ISS:UniProtKB.
 GO:0035090; P:maintenance of apical/basal cell polarity; IMP:MGI.
 GO:0006461; P:protein complex assembly; IEA:Compara. 
Interpro
 IPR000664; Lethal2_giant.
 IPR013577; LLGL2.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF08366; LLGL 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR00962; LETHAL2GIANT.