| Tag | Content |
|---|
| CPLM ID | CPLM-005302 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Macrophage-capping protein |
Protein Synonyms/Alias | Actin regulatory protein CAP-G; Actin-capping protein GCAP39; Myc basic motif homolog 1 |
Gene Name | Capg |
Gene Synonyms/Alias | Mbh1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 301 | CAQIYIWKGRKANEK | acetylation | [1] | | 345 | GRESPIFKQFFKNWK | acetylation | [1] |
|
Reference | [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y. Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [ PMID: 22826441] |
Functional Description | Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA. Uncapping occurs either when Ca(2+) falls or when the concentration of polyphosphoinositide rises, both at low and high Ca(2+). |
Sequence Annotation | REPEAT 27 75 Gelsolin-like 1.
REPEAT 150 190 Gelsolin-like 2.
REPEAT 265 311 Gelsolin-like 3.
MOTIF 139 148 Nuclear localization signal (Potential).
MOD_RES 1 1 N-acetylmethionine (By similarity).
MOD_RES 341 341 Phosphoserine. |
Keyword | Acetylation; Actin capping; Actin-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome; Repeat; Secreted. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 352 AA |
Protein Sequence | MYTPIPQSGS PFPASVQDPG LHIWRVEKLK PVPIARESHG IFFSGDSYLV LHNGPEEASH 60
LHLWIGQQSS RDEQGACAVL AVHLNTLLGE RPVQHREVQG NESDLFMSYF PRGLKYYREG 120
GVESAFHKTT SGARGAAIRK LYQVKGKKNI RATERPLSWD SFNTGDCFIL DLGQNIFAWC 180
GGKSNILERN KARDLALAIR DSERQGKAQV EIITDGEEPA EMIQVLGPKP ALKEGNPEED 240
ITADQTRPNA QAAALYKVSD ATGQMNLTKV ADSSPFASEL LIPDDCFVLD NGLCAQIYIW 300
KGRKANEKER QAALQVADGF ISRMRYSPNT QVEILPQGRE SPIFKQFFKN WK 352 |
Gene Ontology | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. GO:0042470; C:melanosome; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0051693; P:actin filament capping; IEA:UniProtKB-KW. GO:0030031; P:cell projection assembly; IDA:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |