CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042036
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 TIMELESS-interacting protein 
Protein Synonyms/Alias
  
Gene Name
 TIPIN 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
16WAHRLFPKLQFEDFIubiquitination[1, 2]
32RVEYLGSKKEVQTCLubiquitination[3, 4]
106QQRIERNKQLALERRubiquitination[4]
116ALERRQAKLLSNSQTubiquitination[4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 200 AA 
Protein Sequence
MLIRHMEHWA HRLFPKLQFE DFIDRVEYLG SKKEVQTCLK RIRLDLPILH EDFVSNNDEV 60
AENNEHDVTS TELDPFLTNL SESEMFASEL SRSLTEEQQQ RIERNKQLAL ERRQAKLLSN 120
SQTLGNDMLM NTPRAHTVEE VNTDEDQKEE SNGLNEDILD NPCNDAIANT LNEEETLLDQ 180
SFKNVQQQLD ATSRNITEAR 200 
Gene Ontology
 GO:0005794; C:Golgi apparatus; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0007049; P:cell cycle; IEA:InterPro.
 GO:0000077; P:DNA damage checkpoint; IEA:Compara.
 GO:0048478; P:replication fork protection; IEA:InterPro.
 GO:0009411; P:response to UV; IEA:Compara. 
Interpro
 IPR012923; Swi3. 
Pfam
 PF07962; Swi3 
SMART
  
PROSITE
  
PRINTS