CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037796
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Palmitoyl-protein thioesterase 1 
Protein Synonyms/Alias
  
Gene Name
 PPT1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
194HICDFIRKTLNAGAYubiquitination[1, 2]
203LNAGAYSKVVQERLVubiquitination[1, 2, 3, 4, 5]
220EYWHDPIKEDVYRNHubiquitination[2]
253KNLMALKKFVMVKFLubiquitination[2]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 271 AA 
Protein Sequence
MASPGCLWLL AVALLPWTCA SRALQHLDPP APLPLVIWHG MGSRYVAQTG LELLASSNPP 60
ASSYQSAGMI GDSCCNPLSM GAIKKMVEKK IPGIYVLSLE IGKTLMEDVE NSFFLNVNSQ 120
VTTVCQALAK DPKLQQGYNA MGFSQGGQFL RAVAQRCPSP PMINLISVGG QHQGVFGLPR 180
CPGESSHICD FIRKTLNAGA YSKVVQERLV QAEYWHDPIK EDVYRNHSIF LADINQERGI 240
NESYKKNLMA LKKFVMVKFL NDSIVDPVDS E 271 
Gene Ontology
 GO:0008474; F:palmitoyl-(protein) hydrolase activity; IEA:InterPro.
 GO:0006464; P:cellular protein modification process; IEA:InterPro. 
Interpro
 IPR002472; Palm_thioest. 
Pfam
 PF02089; Palm_thioest 
SMART
  
PROSITE
  
PRINTS
 PR00414; PPTHIESTRASE.