CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006938
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 TGF-beta receptor type-2 
Protein Synonyms/Alias
 TGFR-2; TGF-beta type II receptor; Transforming growth factor-beta receptor type II; TGF-beta receptor type II; TbetaR-II 
Gene Name
 Tgfbr2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
277QFETVAVKIFPYEEYsumoylation[1]
Reference
 [1] The type I TGF-beta receptor is covalently modified and regulated by sumoylation.
 Kang JS, Saunier EF, Akhurst RJ, Derynck R.
 Nat Cell Biol. 2008 Jun;10(6):654-64. [PMID: 18469808] 
Functional Description
 Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non- canonical, SMAD-independent TGF-beta signaling pathways (By similarity). 
Sequence Annotation
 DOMAIN 244 546 Protein kinase.
 NP_BIND 250 258 ATP (By similarity).
 ACT_SITE 379 379 Proton acceptor (By similarity).
 BINDING 277 277 ATP (By similarity).
 MOD_RES 548 548 Phosphoserine (By similarity).
 CARBOHYD 70 70 N-linked (GlcNAc...) (Potential).
 CARBOHYD 94 94 N-linked (GlcNAc...) (Potential).
 DISULFID 51 84 By similarity.
 DISULFID 54 71 By similarity.
 DISULFID 61 67 By similarity.
 DISULFID 77 101 By similarity.
 DISULFID 121 136 By similarity.
 DISULFID 138 143 By similarity.  
Keyword
 Apoptosis; ATP-binding; Cell membrane; Complete proteome; Differentiation; Disulfide bond; Glycoprotein; Growth regulation; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 567 AA 
Protein Sequence
MGRGLLRGLW PLHIVLWTRI ASTIPPHVPK SVNSDLMAGD NSGAVKLPQL CKFCDVTLST 60
CDNQKSCMSN CSVTSICEKP QEVCVAVWRK NDKNITLETV CHDPKFTYHG FTLEDATSPT 120
CVMKEKKRAG ETFFMCSCNT EECNDYIIFN EEYTTSSPDL LLVIIQVTGV SLLPPLGIAI 180
AVIAIFYCYR VHRQQKLSPS WESSKPRKLM DFSDNCAIIL EDDRSDISST CANNINHNTE 240
LLPIELDTLV GKGRFAEVYK AKLKQNTSEQ FETVAVKIFP YEEYSSWKTE KDIFSDINLK 300
HENILQFLTA EERKTEMGKQ YWLITAFHAK GNLQEYLTRH VISWEDLRKL GSSLARGIAH 360
LHSDHTPCGR PKMPIVHRDL KSSNILVKND LTCCLCDFGL SLRLDPTLSV DDLANSGQVG 420
TARYMAPEVL ESRMNLENME SFKQTDVYSM ALVLWEMTSR CNAVGEVKDY EPPFGSKVRE 480
HPCVESMKDN VLRDRGRPEI PSFWLNHQGI QIVCETLTEC WDHDPEARLT AQCVAERFSE 540
LEHPDRLSGR SCSQEKIPED GSLNTTK 567 
Gene Ontology
 GO:0005901; C:caveola; IDA:MGI.
 GO:0009986; C:cell surface; IDA:RGD.
 GO:0005829; C:cytosol; IDA:RGD.
 GO:0009897; C:external side of plasma membrane; IEA:Compara.
 GO:0070022; C:transforming growth factor beta receptor homodimeric complex; IC:RGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0005539; F:glycosaminoglycan binding; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0046982; F:protein heterodimerization activity; TAS:RGD.
 GO:0042803; F:protein homodimerization activity; TAS:RGD.
 GO:0004702; F:receptor signaling protein serine/threonine kinase activity; IEA:InterPro.
 GO:0005026; F:transforming growth factor beta receptor activity, type II; IMP:RGD.
 GO:0032147; P:activation of protein kinase activity; IEA:Compara.
 GO:0007568; P:aging; IEP:RGD.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0060434; P:bronchus morphogenesis; IEA:Compara.
 GO:0051216; P:cartilage development; IEA:Compara.
 GO:0007182; P:common-partner SMAD protein phosphorylation; IDA:RGD.
 GO:0048565; P:digestive tract development; IEP:RGD.
 GO:0009790; P:embryo development; IEP:RGD.
 GO:0007566; P:embryo implantation; IEP:RGD.
 GO:0048701; P:embryonic cranial skeleton morphogenesis; IEA:Compara.
 GO:0035162; P:embryonic hemopoiesis; IEA:Compara.
 GO:0007369; P:gastrulation; IEA:Compara.
 GO:0007507; P:heart development; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0002088; P:lens development in camera-type eye; IEA:Compara.
 GO:0030324; P:lung development; IEP:RGD.
 GO:0060463; P:lung lobe morphogenesis; IEA:Compara.
 GO:0060443; P:mammary gland morphogenesis; IEA:Compara.
 GO:0043011; P:myeloid dendritic cell differentiation; IEA:Compara.
 GO:0060044; P:negative regulation of cardiac muscle cell proliferation; IMP:RGD.
 GO:0031100; P:organ regeneration; IEP:RGD.
 GO:0060021; P:palate development; IEA:Compara.
 GO:0060389; P:pathway-restricted SMAD protein phosphorylation; IEA:Compara.
 GO:0001569; P:patterning of blood vessels; IEA:Compara.
 GO:0018105; P:peptidyl-serine phosphorylation; IEA:Compara.
 GO:0018107; P:peptidyl-threonine phosphorylation; IEA:Compara.
 GO:0002663; P:positive regulation of B cell tolerance induction; IEA:Compara.
 GO:0010634; P:positive regulation of epithelial cell migration; IEA:Compara.
 GO:0002053; P:positive regulation of mesenchymal cell proliferation; IEA:Compara.
 GO:0051138; P:positive regulation of NK T cell differentiation; IEA:Compara.
 GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IEA:Compara.
 GO:0043415; P:positive regulation of skeletal muscle tissue regeneration; IEP:RGD.
 GO:0048661; P:positive regulation of smooth muscle cell proliferation; IMP:RGD.
 GO:0002666; P:positive regulation of T cell tolerance induction; IEA:Compara.
 GO:0002651; P:positive regulation of tolerance induction to self antigen; IEA:Compara.
 GO:0006898; P:receptor-mediated endocytosis; IDA:RGD.
 GO:0070723; P:response to cholesterol; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0043627; P:response to estrogen stimulus; IEP:RGD.
 GO:0009749; P:response to glucose stimulus; IEP:RGD.
 GO:0001666; P:response to hypoxia; IEP:RGD.
 GO:0009612; P:response to mechanical stimulus; IEP:RGD.
 GO:0007584; P:response to nutrient; IEP:RGD.
 GO:0023014; P:signal transduction by phosphorylation; IEA:GOC.
 GO:0007224; P:smoothened signaling pathway; IEA:Compara.
 GO:0060440; P:trachea formation; IEA:Compara.
 GO:0007179; P:transforming growth factor beta receptor signaling pathway; IMP:RGD.
 GO:0001570; P:vasculogenesis; IEP:RGD.
 GO:0042060; P:wound healing; IEP:RGD. 
Interpro
 IPR000333; Activin_II/TGFBeta-II_recpt.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR008271; Ser/Thr_kinase_AS.
 IPR017194; Transform_growth_fac-b_typ-2.
 IPR015013; Transforming_GF_b_rcpt_2_ecto. 
Pfam
 PF08917; ecTbetaR2
 PF00069; Pkinase 
SMART
  
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS
 PR00653; ACTIVIN2R.