CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025715
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ceroid-lipofuscinosis, neuronal 8, isoform CRA_a 
Protein Synonyms/Alias
  
Gene Name
 Cln8 
Gene Synonyms/Alias
 mCG_14825 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
253NPYWTHKKTQQLLHPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Membrane; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 288 AA 
Protein Sequence
MTPVSSHGLA ESIFDLDYAS WKIRSTLAVA GFVFYLGVFV VCHQLSSSLN ATYRSLAAKE 60
KVFWNLAATR AVFGVQSTTA GLWALLGDPV LYADKALGQQ NWCWFHITTA TGFFFFENVA 120
VHLSNLFFRT FDLFLVVHHL FAFLGFLGSA INLRAGHYLA MTTLLLEMST PFTCISWMLL 180
KAGWSDSLFW KANQWLMIHM FHCRMILTYH MWWVCFCHWD ALTSSLHLPH WALFLFGLAL 240
LTAVINPYWT HKKTQQLLHP VDWNFAQEEA KGSRQERTNG QVPRKKRL 288 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0007628; P:adult walking behavior; IMP:MGI.
 GO:0001306; P:age-dependent response to oxidative stress; IMP:MGI.
 GO:0008306; P:associative learning; IMP:MGI.
 GO:0044257; P:cellular protein catabolic process; IMP:MGI.
 GO:0006672; P:ceramide metabolic process; IEA:Compara.
 GO:0008203; P:cholesterol metabolic process; IEA:Compara.
 GO:0051935; P:L-glutamate uptake involved in synaptic transmission; IMP:MGI.
 GO:0007040; P:lysosome organization; IMP:MGI.
 GO:0007006; P:mitochondrial membrane organization; IMP:MGI.
 GO:0050881; P:musculoskeletal movement; IMP:MGI.
 GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.
 GO:0051348; P:negative regulation of transferase activity; IMP:MGI.
 GO:0060052; P:neurofilament cytoskeleton organization; IMP:MGI.
 GO:0050885; P:neuromuscular process controlling balance; IMP:MGI.
 GO:0050884; P:neuromuscular process controlling posture; IMP:MGI.
 GO:0006644; P:phospholipid metabolic process; IMP:MGI.
 GO:0045494; P:photoreceptor cell maintenance; IMP:MGI.
 GO:0008361; P:regulation of cell size; IMP:MGI.
 GO:0060041; P:retina development in camera-type eye; IMP:MGI.
 GO:0035176; P:social behavior; IMP:MGI.
 GO:0021523; P:somatic motor neuron differentiation; IMP:MGI. 
Interpro
 IPR006634; TLC-dom. 
Pfam
 PF03798; TRAM_LAG1_CLN8 
SMART
 SM00724; TLC 
PROSITE
 PS50922; TLC 
PRINTS