UniProt Accession

 LEG9_HUMAN; O00182; A7VJG6; O14532; O75028; Q3B8N1; Q53FQ0; Q9NQ58 

Genbank Protein ID

 Z49107; AB006782; AB005894; AB003517; AB008492; AB040130; AB040130; AJ288083; AJ288084; AJ288085; AJ288086; AJ288087; AJ288088; AJ288089; AJ288090; AK223232; CH471159; CH471159; BC105942; BC105944; BC110340 

Genbank Nucleotide ID

 CAA88922.1; BAA22166.1; BAA31542.1; BAF76327.1; BAF76328.1; BAB83625.1; BAB83624.1; CAB93851.1; CAB93851.1; CAB93851.1; CAB93851.1; CAB93851.1; CAB93851.1; CAB93851.1; CAB93851.1; BAD96952.1; EAW51037.1; EAW51044.1; AAI05943.1; AAI05945.1; AAI10341.1 

Protein Name

 Galectin-9 

Protein Synonyms/Alias

 Gal-9; Ecalectin; Tumor antigen HOM-HD-21 

Gene Name

 LGALS9 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
88	SWGPEERKTHMPFQK	ubiquitination	[1]
297	EERSLPRKMPFVRGQ	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Binds galactosides. Has high affinity for the Forssman pentasaccharide. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Inhibits cell proliferation. It is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death. Isoform Short acts as an eosinophil chemoattractant. 

Sequence Annotation

 DOMAIN 17 148 Galectin 1.
 DOMAIN 227 355 Galectin 2.
 REGION 82 88 Beta-galactoside binding 1.
 REGION 287 293 Beta-galactoside binding 2 (By
 BINDING 48 48 Beta-galactoside 1.
 BINDING 61 61 Beta-galactoside 1.
 BINDING 65 65 Beta-galactoside 1.
 BINDING 75 75 Beta-galactoside 1.
 BINDING 267 267 Beta-galactoside 2.
 BINDING 271 271 Beta-galactoside 2.
 BINDING 281 281 Beta-galactoside 2 (By similarity).  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Lectin; Polymorphism; Reference proteome; Repeat; Secreted. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 355 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0005534; F:galactose binding; TAS:ProtInc.
 GO:0004871; F:signal transducer activity; IMP:UniProtKB.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:UniProtKB. 

Interpro

 IPR008985; ConA-like_lec_gl_sf.
 IPR013320; ConA-like_subgrp.
 IPR001079; Galectin_CRD. 

Pfam

 PF00337; Gal-bind_lectin 

SMART

 SM00908; Gal-bind_lectin
 SM00276; GLECT 

PROSITE

 PS51304; GALECTIN 

PRINTS