CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026143
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 UDP-N-acetylmuramate--alanine ligase 
Protein Synonyms/Alias
  
Gene Name
 TTHA1085 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) 
NCBI Taxa ID
 300852 
Lysine Modification
Position
Peptide
Type
References
196HESLEALKEAMRGFLacetylation[1]
Reference
 [1] Acetylome with structural mapping reveals the significance of lysine acetylation in Thermus thermophilus.
 Okanishi H, Kim K, Masui R, Kuramitsu S.
 J Proteome Res. 2013 Aug 1;. [PMID: 23901841] 
Functional Description
 Cell wall formation (By similarity). 
Sequence Annotation
  
Keyword
 ATP-binding; Cell cycle; Cell division; Cell shape; Cell wall biogenesis/degradation; Complete proteome; Cytoplasm; Ligase; Nucleotide-binding; Peptidoglycan synthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 446 AA 
Protein Sequence
MRKAHIMGIE GVGMSALARL LMAEGVAVTG CDLAPGPRAR RLGVPVHHGH DPGHLADEDT 60
LVVPTPVPPD HPEVVEARKR GLRVLRRMEL LAHFLAQRPS AGVTGTHGKT TTTGMLAAIL 120
LEAGLDPWVF LGGELALLPG NARPGRGPRV AEVDESDPLF REVRVSVAVA TNLEADHVAP 180
RGERAPNYHE SLEALKEAMR GFLAGAKTVV VPAMDPGLLA LTEGLPRRLF GPGGEVWAEA 240
VDLSPSGASF RLVHREGPLG EVHLRVPGRH NVHNALAAAL AALALGASPE AISRGLSRFP 300
GVGRRFERVG EVGGAWVVDD YAHHPTEVQA TLEAALLSGR RVRVFFQPHR LLRTQELWEA 360
FAQALKGAHE VVVLPVYTAG ERGRESPEAL SDRIAKRLED LGRPARRMDK EEALAYARAT 420
ARPEDLLLFM GAGDVTLLAR RLVHEG 446 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008763; F:UDP-N-acetylmuramate-L-alanine ligase activity; IEA:InterPro.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW. 
Interpro
 IPR004101; Mur_ligase_C.
 IPR013221; Mur_ligase_cen.
 IPR000713; Mur_ligase_N.
 IPR016040; NAD(P)-bd_dom.
 IPR005758; UDP-N-AcMur_Ala_ligase. 
Pfam
 PF01225; Mur_ligase
 PF02875; Mur_ligase_C
 PF08245; Mur_ligase_M 
SMART
  
PROSITE
  
PRINTS