CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020062
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Junctophilin-2 
Protein Synonyms/Alias
 JP-2; Junctophilin type 2 
Gene Name
 JPH2 
Gene Synonyms/Alias
 JP2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
647TEARGLTKAGAKKKAacetylation[1, 2]
651GLTKAGAKKKARKEAacetylation[1, 2]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH2 is necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release. Contributes to the construction of skeletal muscle triad junctions. 
Sequence Annotation
 REPEAT 14 36 MORN 1.
 REPEAT 38 59 MORN 2.
 REPEAT 60 79 MORN 3.
 REPEAT 82 104 MORN 4.
 REPEAT 106 128 MORN 5.
 REPEAT 129 151 MORN 6.
 REPEAT 291 313 MORN 7.
 REPEAT 314 336 MORN 8.
 MOD_RES 165 165 Phosphoserine.
 MOD_RES 469 469 Phosphoserine.
 MOD_RES 484 484 Phosphoserine.
 MOD_RES 486 486 Phosphoserine.
 MOD_RES 490 490 Phosphothreonine.  
Keyword
 Alternative splicing; Cardiomyopathy; Cell membrane; Complete proteome; Disease mutation; Endoplasmic reticulum; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Sarcoplasmic reticulum; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 696 AA 
Protein Sequence
MSGGRFDFDD GGAYCGGWEG GKAHGHGLCT GPKGQGEYSG SWNFGFEVAG VYTWPSGNTF 60
EGYWSQGKRH GLGIETKGRW LYKGEWTHGF KGRYGIRQSS SSGAKYEGTW NNGLQDGYGT 120
ETYADGGTYQ GQFTNGMRHG YGVRQSVPYG MAVVVRSPLR TSLSSLRSEH SNGTVAPDSP 180
ASPASDGPAL PSPAIPRGGF ALSLLANAEA AARAPKGGGL FQRGALLGKL RRAESRTSVG 240
SQRSRVSFLK SDLSSGASDA ASTASLGEAA EGADEAAPFE ADIDATTTET YMGEWKNDKR 300
SGFGVSERSS GLRYEGEWLD NLRHGYGCTT LPDGHREEGK YRHNVLVKDT KRRMLQLKSN 360
KVRQKVEHSV EGAQRAAAIA RQKAEIAASR TSHAKAKAEA AEQAALAANQ ESNIARTLAR 420
ELAPDFYQPG PEYQKRRLLQ EILENSESLL EPPDRGAGAA GLPQPPRESP QLHERETPRP 480
EGGSPSPAGT PPQPKRPRPG VSKDGLLSPG AWNGEPSGEG SRSVTPSEGA GRRSPARPAT 540
ERMAIEALQA PPAPSREPEV ALYQGYHSYA VRTTPPEPPP FEDQPEPEVS GSESAPSSPA 600
TAPLQAPTLR GPEPARETPA KLEPKPIIPK AEPRAKARKT EARGLTKAGA KKKARKEAAL 660
AAEAEVEVEE VPNTILICMV ILLNIGLAIL FVHLLT 696 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0030314; C:junctional membrane complex; IEA:Compara.
 GO:0014701; C:junctional sarcoplasmic reticulum membrane; TAS:BHF-UCL.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0030018; C:Z disc; IEA:Compara.
 GO:0015278; F:calcium-release channel activity; IDA:UniProtKB.
 GO:0060402; P:calcium ion transport into cytosol; TAS:BHF-UCL.
 GO:0060316; P:positive regulation of ryanodine-sensitive calcium-release channel activity; IDA:UniProtKB.
 GO:0055024; P:regulation of cardiac muscle tissue development; IEA:Compara. 
Interpro
 IPR017191; Junctophilin.
 IPR003409; MORN. 
Pfam
 PF02493; MORN 
SMART
 SM00698; MORN 
PROSITE
  
PRINTS