CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031215
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Far upstream element-binding protein 1 
Protein Synonyms/Alias
 cDNA FLJ53425, highly similar to Far upstream element-binding protein 1 
Gene Name
 FUBP1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
44RARQIAAKIGGDAGTacetylation[1]
44RARQIAAKIGGDAGTubiquitination[2]
64DYGYGGQKRPLEDGDubiquitination[3]
182PESVQSAKRLLDQIVubiquitination[4]
224KAGLVIGKGGETIKQubiquitination[2, 3, 5, 6, 7]
230GKGGETIKQLQERAGubiquitination[4, 6, 7, 8]
264RITGDPYKVQQAKEMacetylation[7]
333AGVRIQFKPDDGTTPacetylation[1]
333AGVRIQFKPDDGTTPubiquitination[2, 5, 6, 7]
415KTGLIIGKGGETIKSubiquitination[4, 7]
421GKGGETIKSISQQSGacetylation[1]
421GKGGETIKSISQQSGubiquitination[2, 4, 6, 7]
446PNADPNMKLFTIRGTacetylation[1]
446PNADPNMKLFTIRGTubiquitination[4, 8]
612KAWEEYYKKMGQAVPacetylation[7]
613AWEEYYKKMGQAVPAubiquitination[6]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [5] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [6] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [7] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [8] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 665 AA 
Protein Sequence
MADYSTVPPP SSGSAGGGGG GGGGGGVNDA FKDALQRARQ IAAKIGGDAG TSLNSNDYGY 60
GGQKRPLEDG DGSWTSPSST THWEGMPSPF KDQPDAKKVA PQNDSFGTQL PPMHQQQSRS 120
VMTEEYKVPD GMVGFIIGRG GEQISRIQQE SGCKIQIAPD SGGLPERSCM LTGTPESVQS 180
AKRLLDQIVE KGRPAPGFHH GDGPGNAVQE IMIPASKAGL VIGKGGETIK QLQERAGVKM 240
VMIQDGPQNT GADKPLRITG DPYKVQQAKE MVLELIRDQG GFREVRNEYG SRIGGNEGID 300
VPIPRFAVGI VIGRNGEMIK KIQNDAGVRI QFKPDDGTTP ERIAQITGPP DRCQHAAEII 360
TDLLRSVQAG NPGGPGPGGR GRGRGQGNWN MGPPGGLQEF NFIVPTGKTG LIIGKGGETI 420
KSISQQSGAR IELQRNPPPN ADPNMKLFTI RGTPQQIDYA RQLIEEKIGG PVNPLGPPVP 480
HGPHGVPGPH GPPGPPGPGT PMGPYNPAPY NPGPPGPAPH GPPAPYAPQG WGNAYPHWQQ 540
QAPPDPAKAG TDPNSAAWAA YYAHYYQQQA QPPPAAPAGA PTTTQTNGQG DQQNPAPAGQ 600
VDYTKAWEEY YKKMGQAVPA PTGAPPGGQP DYSAAWAEYY RQQAAYYAQT SPQGMPQHPP 660
APQGQ 665 
Gene Ontology
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0003723; F:RNA binding; IEA:InterPro. 
Interpro
 IPR015096; DUF1897.
 IPR004087; KH_dom.
 IPR004088; KH_dom_type_1. 
Pfam
 PF09005; DUF1897
 PF00013; KH_1 
SMART
 SM00322; KH 
PROSITE
 PS50084; KH_TYPE_1 
PRINTS