UniProt Accession

 RELB_ECOLI; P0C079; P07007 

Genbank Protein ID

 X02405; U00096; AP009048 

Genbank Nucleotide ID

 CAA26250.1; AAC74637.1; BAA15263.1 

Protein Name

 Antitoxin RelB 

Protein Synonyms/Alias

  

Gene Name

 relB 

Gene Synonyms/Alias

 b1564; JW1556 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
13	LRIDDELKARSYAAL	acetylation	[1]
63	AELVEIVKERLRNPK	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Antitoxin component of a toxin-antitoxin (TA) module. Counteracts the effect of RelE via direct protein-protein interaction, enabling the reversion of translation inhibition. Also acts as an autorepressor of relBE transcription. DNA-binding and repression is stronger when complexed with corepressor RelE. Increased transcription rate of relBE and activation of relE is consistent with a lower level of RelB in starved cells due to degradation of RelB by protease Lon. 

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; DNA-binding; Reference proteome; Repressor; Stress response; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 79 AA 

Protein Sequence

Gene Ontology

 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006950; P:response to stress; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; EXP:EcoCyc. 

Interpro

 IPR007337; RelB/DinJ. 

Pfam

 PF04221; RelB 

SMART

  

PROSITE

  

PRINTS