UniProt Accession

 ARP8_HUMAN; Q9H981; B3KSW7; Q8N566; Q9H663 

Genbank Protein ID

 AK022996; AK094507; AK026232; AC012467; BC032744 

Genbank Nucleotide ID

 BAB14352.1; BAG52879.1; BAB15402.1; AAH32744.1 

Protein Name

 Actin-related protein 8 

Protein Synonyms/Alias

 hArp8; INO80 complex subunit N 

Gene Name

 ACTR8 

Gene Synonyms/Alias

 ARP8; INO80N 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
88	QQGQPLYKDSWLLRE	ubiquitination	[1]
99	LLREGLNKPESNEQR	ubiquitination	[1]
225	KYLEIPLKDLKYYRC	ubiquitination	[2, 3]
337	RECQLTNKMDCLLLQ	ubiquitination	[1]
404	TFGIVGQKMTTLQHR	ubiquitination	[1]
431	YLLATQSKQEQSAKA	ubiquitination	[2]
498	LTALMSRKTAISLFE	ubiquitination	[1]
558	LQHRILNKMPPSFRR	ubiquitination	[2]
577	VDVITRPKDMDPRLI	ubiquitination	[3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize. 

Sequence Annotation

 NP_BIND 283 286 ATP.
 BINDING 55 55 ATP.
 BINDING 56 56 ATP.
 MOD_RES 132 132 Phosphoserine.
 MOD_RES 412 412 Phosphoserine.  

Keyword

 3D-structure; Alternative splicing; ATP-binding; Cell cycle; Cell division; Chromosome; Complete proteome; DNA damage; DNA recombination; DNA repair; Mitosis; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 624 AA 

Protein Sequence

Gene Ontology

 GO:0031011; C:Ino80 complex; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
 GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR004000; Actin-related. 

Pfam

 PF00022; Actin 

SMART

 SM00268; ACTIN 

PROSITE

  

PRINTS