| Tag | Content |
|---|
| CPLM ID | CPLM-012774 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Xaa-Pro aminopeptidase 1 |
Protein Synonyms/Alias | Aminoacylproline aminopeptidase; Cytosolic aminopeptidase P; Soluble aminopeptidase P; sAmp; X-Pro aminopeptidase 1; X-prolyl aminopeptidase 1, soluble |
Gene Name | XPNPEP1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Bos taurus (Bovine) |
NCBI Taxa ID | 9913 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 546 | VVLVVPVKTKYNFNN | ubiquitination | [1] | | 548 | LVVPVKTKYNFNNRG | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Contributes to the degradation of bradykinin. Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro (By similarity). |
Sequence Annotation | METAL 415 415 Manganese 1 (By similarity).
METAL 426 426 Manganese 1 (By similarity).
METAL 426 426 Manganese 2 (By similarity).
METAL 489 489 Manganese 2 (By similarity).
METAL 523 523 Manganese 1 (By similarity).
METAL 523 523 Manganese 2 (By similarity).
METAL 537 537 Manganese 1 (By similarity).
METAL 537 537 Manganese 2 (By similarity).
MOD_RES 304 304 N6-acetyllysine (By similarity). |
Keyword | Acetylation; Aminopeptidase; Complete proteome; Cytoplasm; Hydrolase; Manganese; Metal-binding; Metalloprotease; Protease; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 623 AA |
Protein Sequence | MAPKITSELL RQLRQAMRNL EYVTEPIQAY IIPSGDAHQS EYIAPCDCRR AFVSGFDGSA 60
GTAIVTEEHA AMWTDGRYFL QAAKQMDSNW TLMKMGLKDT PTQEDWLVSV LPEGSRVGVD 120
PLIIPTDYWK KMAKVLRSAG HHLIPVKDNL VDKIWTDRPE RPCKPLITLG LDYTGISWKD 180
KVADLRLKMA ERNVVWFVVT ALDEIAWLFN LRGSDVEHNP VFFSYAILGL ETIMLFIDGD 240
RIDAPIVKEH LLLDLGLEAE YRIQVLPYKS ILSELKILCA SLSPREKVWV SDKASYAVSE 300
AIPKDHRCCM PYTPICIAKA VKNSAESEGM RRAHIKDAVA LCELFNWLEK EVPKGGVTEI 360
SAANKAEEFR RQQADFVDLS FPTISSTGPN GAIIHYAPVP ETNRTLSLDE VYLIDSGAQY 420
KDGTTDVTRT MHFGTPTAYE KECFTYVLKG HIAVSAAVFP TGTKGHLLDS FARSALWDSG 480
LDYLHGTGHG VGSFLNVHEG PCGISYKTFS DEPLEAGMIV TDEPGYYEDG AFGIRIENVV 540
LVVPVKTKYN FNNRGSLTFE PLTLVPIQTK MIDVDSLTDK ECDWLNSYHL TCRDVIGKEL 600
QKQGRQEALE WLIRETQPIS KQP 623 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0030145; F:manganese ion binding; ISS:UniProtKB. GO:0070006; F:metalloaminopeptidase activity; ISS:UniProtKB. GO:0010815; P:bradykinin catabolic process; ISS:UniProtKB. GO:0006508; P:proteolysis; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |