CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015342
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Atlastin-1 
Protein Synonyms/Alias
 Spastic paraplegia 3A homolog 
Gene Name
 Atl1 
Gene Synonyms/Alias
 Spg3a 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
287PNFDGKLKEIDDEFIacetylation[1]
400QLKEDSVKLFRGVKKacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 GTPase tethering membranes through formation of trans- homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. 
Sequence Annotation
 NP_BIND 74 81 GTP (Potential).
 NP_BIND 146 150 GTP (Potential).
 REGION 1 447 Redistribution to soluble cell fraction
 REGION 448 558 Sufficient for membrane association (By
 MOD_RES 10 10 Phosphoserine (By similarity).
 MOD_RES 18 18 Phosphoserine (By similarity).
 MOD_RES 22 22 Phosphoserine (By similarity).
 MOD_RES 23 23 Phosphoserine (By similarity).  
Keyword
 Cell projection; Coiled coil; Complete proteome; Endoplasmic reticulum; Golgi apparatus; GTP-binding; Hydrolase; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 558 AA 
Protein Sequence
MAKSRRDRNS WGGFSEKSSD WSSEEEEPVR KAGPVQVLIV KDDHSFELDE AALNRILLSE 60
AVRDKEVVAV SVAGAFRKGK SFLMDFMLRY MYNQESVDWV GDYNEPLTGF SWRGGSERET 120
TGIQIWSEVF LINKLDGKKV AVLLMDTQGT FDSQSTLRDS ATVFALSTMI SSIQVYNLSQ 180
NVQEDDLQHL QLFTEYGRLA MEETFLKPFQ SLIFLVRDWS FPYEFSYGAD GGAKFLEKRL 240
KVSGNQHEEL QNVRKHIHSC FTNISCFLLP HPGLKVATNP NFDGKLKEID DEFIKNLKIL 300
IPWLLSPESL DIKEINGNKI TCRGLLEYFK AYIKIYQGEE LPHPKSMLQA TAEANNLAAV 360
ATAKDTYNKK MEEICGGDKP FLAPNDLQTK HLQLKEDSVK LFRGVKKMGG EEFSRRYLQQ 420
LESEIDELYI QYIKHNDSKN IFHAARTPAT LFVVIFITYV IAGVTGFIGL DIIASLCNMI 480
MGLTLITLCT WAYIRYSGEY RELGAVIDQV AAALWDQGST NEALYKLYSA AATHRHLYQQ 540
AFPAPKSEPT EQPEKKKI 558 
Gene Ontology
 GO:0030424; C:axon; IEA:UniProtKB-SubCell.
 GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB.
 GO:0000137; C:Golgi cis cisterna; IDA:UniProtKB.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; ISS:UniProtKB.
 GO:0005525; F:GTP binding; IMP:UniProtKB.
 GO:0003924; F:GTPase activity; IDA:UniProtKB.
 GO:0042802; F:identical protein binding; ISS:UniProtKB.
 GO:0007409; P:axonogenesis; IMP:UniProtKB.
 GO:0007029; P:endoplasmic reticulum organization; ISS:UniProtKB.
 GO:0051260; P:protein homooligomerization; ISS:UniProtKB. 
Interpro
 IPR003191; Guanylate-bd_C.
 IPR015894; Guanylate-bd_N.
 IPR027417; P-loop_NTPase. 
Pfam
 PF02263; GBP 
SMART
  
PROSITE
  
PRINTS