UniProt Accession

 5NT3A_HUMAN; Q9H0P0; A8K253; B2RAA5; B8ZZC4; Q6IPZ1; Q6NXS6; Q7L3G6; Q9P0P5; Q9UC42; Q9UC43; Q9UC44; Q9UC45 

Genbank Protein ID

 AF312735; AL136716; AK290118; AK314109; CR533518; AC074338; AC083863; CH471073; CH471073; BC013292; BC015856; BC066914; BC071652; AF151067 

Genbank Nucleotide ID

 AAG33630.1; CAB66650.1; BAF82807.1; BAG36802.1; CAG38549.1; EAW94007.1; EAW94008.1; AAH13292.2; AAH15856.2; AAH66914.1; AAH71652.2; AAF36153.1 

Protein Name

 Cytosolic 5'-nucleotidase 3A 

Protein Synonyms/Alias

 Cytosolic 5'-nucleotidase 3; Cytosolic 5'-nucleotidase III; cN-III; Pyrimidine 5'-nucleotidase 1; P5'N-1; P5N-1; PN-I; Uridine 5'-monophosphate hydrolase 1; p36 

Gene Name

 NT5C3A 

Gene Synonyms/Alias

 NT5C3; P5N1; UMPH1; HSPC233 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
91	KLLQLKEKYYAIEVD	ubiquitination	[1]
116	YMVEWYTKSHGLLVQ	ubiquitination	[1]
132	ALPKAKLKEIVAESD	ubiquitination	[1]
201	FDETGVLKGFKGELI	ubiquitination	[1]
228	TEYFNQLKDNSNIIL	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Can act both as nucleotidase and as phosphotransferase. 

Sequence Annotation

 REGION 203 204 Substrate binding.
 ACT_SITE 88 88 Nucleophile.
 ACT_SITE 90 90 Proton donor.
 METAL 88 88 Magnesium.
 METAL 90 90 Magnesium; via carbonyl oxygen.
 METAL 277 277 Magnesium.
 BINDING 252 252 Substrate.  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Endoplasmic reticulum; Hydrolase; Magnesium; Metal-binding; Nucleotide metabolism; Nucleotide-binding; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 336 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0008665; F:2'-phosphotransferase activity; NAS:UniProtKB.
 GO:0008253; F:5'-nucleotidase activity; IDA:UniProtKB.
 GO:0000287; F:magnesium ion binding; NAS:UniProtKB.
 GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
 GO:0009117; P:nucleotide metabolic process; IEA:UniProtKB-KW.
 GO:0006206; P:pyrimidine nucleobase metabolic process; TAS:Reactome.
 GO:0046135; P:pyrimidine nucleoside catabolic process; TAS:Reactome. 

Interpro

 IPR023214; HAD-like_dom.
 IPR006434; Pyrimidine_nucleotidase_eu. 

Pfam

 PF05822; UMPH-1 

SMART

  

PROSITE

  

PRINTS