CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038856
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Tyrosine-protein kinase receptor 
Protein Synonyms/Alias
  
Gene Name
 Insr 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
911VETRVAVKTVNESASubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1236 AA 
Protein Sequence
MNITRGSVRI EKNNELCYLA TIDWSRILDS VEDNYIVLNK DDNEECGDVC PGTAKGKTNC 60
PATVINGQFV ERCWTHSHCQ KVCPTICKSH GCTAEGLCCH KECLGNCSEP DDPTKCVACR 120
NFYLDGQCVE TCPPPYYHFQ DWRCVNFSFC QDLHYKCRNS RKPGCHQYVI HNNKCIPECP 180
SGYTMNSSNL MCTPCLGPCP KVCQILEGEK TIDSVTSAQE LRGCTVINGS LIINIRGGNN 240
LAAELEANLG LIEEISGFLK IRRSYALVSL SFFRKLHLIR GETLEIGNYS FYALDNQNLR 300
QLWDWNKHNL TITQGKLFFH YNPKLCLSEI HKMEEVSGTK GRQERNDIAL KTNGDQASCE 360
NELLKFSFIR TSFDKILLRW EPYWPPDFRD LLGFMLFYKE APYQNVTEFD GQDACGSNSW 420
TVVDIDPPQR SNDPKSQTPS HPGWLMRGLK PWTQYAIFVK TLVTFSDERR TYGAKSDIIY 480
VQTDATNPSV PLDPISVSNS SSQIILKWKP PSDPNGNITH YLVYWERQAE DSELFELDYC 540
LKGLKLPSRT WSPPFESDDS QKHNQSEYDD SASECCSCPK TDSQILKELE ESSFRKTFED 600
YLHNVVFVPR PSRKRRSLEE VGNVTATTPT LPDFPNISST IAPTSHEEHR PFEKVVNKES 660
LVISGLRHFT GYRIELQACN QDSPEERCSV AAYVSARTMP EAKADDIVGP VTHEIFENNV 720
VHLMWQEPKE PNGLIVLYEV SYRRYGDEEL HLCVSRKHFA LERGCRLRGL SPGNYSVRVR 780
ATSLAGNGSW TEPTYFYVTD YLDVPSNIAK IIIGPLIFVF LFSVVIGSIY LFLRKRQPDG 840
PMGPLYASSN PEYLSASDVF PSSVYVPDEW EVPREKITLL RELGQGSFGM VYEGNAKDII 900
KGEVETRVAV KTVNESASLR ERIEFLNEAS VMKGFTCHHV VRLLGVVSKG QPTLVVMELM 960
AHGDLKSHLR SLRPDAENNP GRPPPTLQEM IQMTAEIADG MAYLNAKKFV HRDLAARNCM 1020
VAHDFTVKIG DFGMTRDIYE TDYYRKGGKG LLPVRWMSPE SLKDGVFTAS SDMWSFGVVL 1080
WEITSLAEQP YQGLSNEQVL KFVMDGGYLD PPDNCPERLT DLMRMCWQFN PKMRPTFLEI 1140
VNLLKDDLHP SFPEVSFFYS EENKAPESEE LEMEFEDMEN VPLDRSSHCQ REEAGCREGG 1200
SSLSIKRTYD EHIPYTHMNG GKKNGRVLTL PRSNPS 1236 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:EC.
 GO:0046777; P:protein autophosphorylation; IEA:InterPro.
 GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro. 
Interpro
 IPR000494; EGF_rcpt_L.
 IPR003961; Fibronectin_type3.
 IPR006211; Furin-like_Cys-rich_dom.
 IPR006212; Furin_repeat.
 IPR009030; Growth_fac_rcpt_N_dom.
 IPR013783; Ig-like_fold.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom.
 IPR016246; Tyr_kinase_insulin-like_rcpt.
 IPR002011; Tyr_kinase_rcpt_2_CS. 
Pfam
 PF00041; fn3
 PF00757; Furin-like
 PF07714; Pkinase_Tyr
 PF01030; Recep_L_domain 
SMART
 SM00060; FN3
 SM00261; FU
 SM00219; TyrKc 
PROSITE
 PS50853; FN3
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR
 PS00239; RECEPTOR_TYR_KIN_II 
PRINTS
 PR00109; TYRKINASE.