UniProt Accession

 CAH3_RAT; P14141; O54961; Q9QV77 

Genbank Protein ID

 M22413; AB030829; AB030830; AF037072; BC061980 

Genbank Nucleotide ID

 AAA40846.1; BAB08111.1; BAB20673.1; AAB92558.1; AAH61980.1 

Protein Name

 Carbonic anhydrase 3 

Protein Synonyms/Alias

 Carbonate dehydratase III; Carbonic anhydrase III; CA-III 

Gene Name

 Ca3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
3	*****MAKEWGYASH	acetylation	[1]
24	HELYPIAKGDNQSPI	acetylation	[1]
36	SPIELHTKDIRHDPS	acetylation	[1]
57	SYDPGSAKTILNNGK	acetylation	[1]
126	HLVHWNPKYNTFGEA	acetylation	[1]
135	NTFGEALKQPDGIAV	acetylation	[1]
153	FLKIGREKGEFQILL	acetylation	[1]
165	ILLDALDKIKTKGKE	acetylation	[1]
167	LDALDKIKTKGKEAP	acetylation	[1]
224	VSSDQMAKLRSLFAS	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Reversible hydration of carbon dioxide. A major participant in the liver response to oxidative stress. 

Sequence Annotation

 REGION 64 67 Involved in proton transfer (By
 REGION 198 199 Substrate binding (By similarity).
 ACT_SITE 127 127 By similarity.
 METAL 94 94 Zinc; catalytic.
 METAL 96 96 Zinc; catalytic.
 METAL 119 119 Zinc; catalytic.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 182 182 S-glutathionyl cysteine.
 MOD_RES 187 187 S-glutathionyl cysteine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; Glutathionylation; Lyase; Metal-binding; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 260 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:RGD.
 GO:0004089; F:carbonate dehydratase activity; TAS:RGD.
 GO:0016151; F:nickel cation binding; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006730; P:one-carbon metabolic process; IEA:InterPro.
 GO:0045471; P:response to ethanol; IEP:RGD.
 GO:0006979; P:response to oxidative stress; IMP:RGD. 

Interpro

 IPR001148; Carbonic_anhydrase_a.
 IPR023561; Carbonic_anhydrase_a-class.
 IPR018338; Carbonic_anhydrase_a-class_CS.
 IPR018441; Carbonic_anhydrase_CA3. 

Pfam

 PF00194; Carb_anhydrase 

SMART

 SM01057; Carb_anhydrase 

PROSITE

 PS00162; ALPHA_CA_1
 PS51144; ALPHA_CA_2 

PRINTS