UniProt Accession

 DEOR_ECOLI; P0ACK5; P06217 

Genbank Protein ID

 X02837; U00096; AP009048 

Genbank Nucleotide ID

 CAA26598.1; AAC73927.1; BAA35543.1 

Protein Name

 Deoxyribose operon repressor 

Protein Synonyms/Alias

  

Gene Name

 deoR 

Gene Synonyms/Alias

 nucR; b0840; JW0824 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
17	GQLLQELKRSDKLHL	acetylation	[1]
72	HYLLSDQKSRLVEEK	acetylation	[1]
79	KSRLVEEKRRAAKLA	acetylation	[1]
211	VLVVDHSKFGKVRPA	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 This protein is one of the repressors that regulate the expression of deoCABD genes, which encode nucleotide and deoxy ribonucleotide catabolizing enzymes. It also negatively regulates the expression of nupG (a transport protein) and tsx (a pore- forming protein). The inducer is deoxyribose-5-phosphate. 

Sequence Annotation

 DOMAIN 5 57 HTH deoR-type.
 DNA_BIND 22 41 H-T-H motif (By similarity).  

Keyword

 Complete proteome; DNA-binding; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 252 AA 

Protein Sequence

Gene Ontology

 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0000986; F:bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding; IDA:EcoCyc.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:2000143; P:negative regulation of DNA-dependent transcription, initiation; IMP:EcoCyc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR014036; DeoR_C.
 IPR001034; HTH_DeoR_N.
 IPR018356; Tscrpt_reg_HTH_DeoR_CS. 

Pfam

 PF00455; DeoRC
 PF08220; HTH_DeoR 

SMART

 SM00420; HTH_DEOR 

PROSITE

 PS00894; HTH_DEOR_1
 PS51000; HTH_DEOR_2 

PRINTS