UniProt Accession

 H2B6_ARATH; O23629 

Genbank Protein ID

 Y12576; AL162459; CP002686; BT006400; AY087219 

Genbank Nucleotide ID

 CAA73156.1; CAB82822.1; AEE78097.1; AAP21208.1; AAM64775.1 

Protein Name

 Histone H2B.6 

Protein Synonyms/Alias

 H2BAt; HTB9 

Gene Name

 H2B 

Gene Synonyms/Alias

 At3g45980; F16L2.190 

Created Date

 July 27, 2013 

Organism

 Arabidopsis thaliana (Mouse-ear cress) 

NCBI Taxa ID

 3702 

Lysine Modification

Position	Peptide	Type	References
7	*MAPRAEKKPAEKKP	acetylation	[1, 2]
12	AEKKPAEKKPAAEKP	acetylation	[1, 2]
28	EEKSKAEKAPAEKKP	acetylation	[1, 2]
33	AEKAPAEKKPKAGKK	acetylation	[1, 2]
39	EKKPKAGKKLPKEAG	acetylation	[1]
40	KKPKAGKKLPKEAGA	acetylation	[1]

Reference

 [1] Characterization of post-translational modifications of histone H2B-variants isolated from Arabidopsis thaliana.
 Bergmüller E, Gehrig PM, Gruissem W.
 J Proteome Res. 2007 Sep;6(9):3655-68. [PMID: 17691833]
 [2] Distinctive core histone post-translational modification patterns in Arabidopsis thaliana.
 Zhang K, Sridhar VV, Zhu J, Kapoor A, Zhu JK.
 PLoS One. 2007 Nov 21;2(11):e1210. [PMID: 18030344] 

Functional Description

 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. 

Sequence Annotation

 MOD_RES 2 2 N,N,N-trimethylalanine; alternate.
 MOD_RES 2 2 N,N-dimethylalanine; alternate.
 MOD_RES 2 2 N-methylalanine; alternate.
 MOD_RES 7 7 N6-acetyllysine.
 MOD_RES 12 12 N6-acetyllysine.
 MOD_RES 28 28 N6-acetyllysine.
 MOD_RES 33 33 N6-acetyllysine.
 MOD_RES 39 39 N6-acetyllysine.
 MOD_RES 40 40 N6-acetyllysine; partial.
 CROSSLNK 146 146 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Acetylation; Chromosome; Complete proteome; DNA-binding; Isopeptide bond; Methylation; Nucleosome core; Nucleus; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 150 AA 

Protein Sequence

Gene Ontology

 GO:0009570; C:chloroplast stroma; IDA:TAIR.
 GO:0009534; C:chloroplast thylakoid; IDA:TAIR.
 GO:0005730; C:nucleolus; IDA:TAIR.
 GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006334; P:nucleosome assembly; IEA:InterPro. 

Interpro

 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR000558; Histone_H2B. 

Pfam

 PF00125; Histone 

SMART

 SM00427; H2B 

PROSITE

 PS00357; HISTONE_H2B 

PRINTS

 PR00621; HISTONEH2B.