| Tag | Content |
|---|
| CPLM ID | CPLM-015094 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | RGM domain family member B |
Protein Synonyms/Alias | DRG11-responsive axonal guidance and outgrowth of neurite; DRAGON |
Gene Name | RGMB |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 175 | DPHLRTFKDNFQTCK | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth. |
Sequence Annotation | LIPID 413 413 GPI-anchor amidated asparagine
CARBOHYD 120 120 N-linked (GlcNAc...) (Potential).
CARBOHYD 383 383 N-linked (GlcNAc...) (Potential). |
Keyword | 3D-structure; Cell membrane; Complete proteome; Glycoprotein; GPI-anchor; Lipoprotein; Membrane; Reference proteome; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 437 AA |
Protein Sequence | MGLRAAPSSA AAAAAEVEQR RSPGLCPPPL ELLLLLLFSL GLLHAGDCQQ PAQCRIQKCT 60
TDFVSLTSHL NSAVDGFDSE FCKALRAYAG CTQRTSKACR GNLVYHSAVL GISDLMSQRN 120
CSKDGPTSST NPEVTHDPCN YHSHAGAREH RRGDQNPPSY LFCGLFGDPH LRTFKDNFQT 180
CKVEGAWPLI DNNYLSVQVT NVPVVPGSSA TATNKITIIF KAHHECTDQK VYQAVTDDLP 240
AAFVDGTTSG GDSDAKSLRI VERESGHYVE MHARYIGTTV FVRQVGRYLT LAIRMPEDLA 300
MSYEESQDLQ LCVNGCPLSE RIDDGQGQVS AILGHSLPRT SLVQAWPGYT LETANTQCHE 360
KMPVKDIYFQ SCVFDLLTTG DANFTAAAHS ALEDVEALHP RKERWHIFPS SGNGTPRGGS 420
DLSVSLGLTC LILIVFL 437 |
Gene Ontology | GO:0046658; C:anchored to plasma membrane; ISS:HGNC. GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; ISS:HGNC. GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell. GO:0042802; F:identical protein binding; ISS:HGNC. GO:0007411; P:axon guidance; TAS:Reactome. GO:0030509; P:BMP signaling pathway; ISS:HGNC. GO:0007155; P:cell adhesion; ISS:HGNC. GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:HGNC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |