CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004842
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc/cadmium resistance protein 
Protein Synonyms/Alias
  
Gene Name
 ZRC1 
Gene Synonyms/Alias
 YMR243C; YM9408.05C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
67KNRGPDAKYTYGWKRubiquitination[1]
357SSAKLIRKIFHQHGIubiquitination[2]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047] 
Functional Description
 Probably responsible for the uptake of zinc and cadmium ions. 
Sequence Annotation
 MOD_RES 387 387 Phosphoserine.
 MOD_RES 393 393 Phosphoserine.
 MOD_RES 397 397 Phosphoserine.  
Keyword
 Cadmium; Cadmium resistance; Complete proteome; Ion transport; Membrane; Mitochondrion; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Transport; Zinc; Zinc transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 442 AA 
Protein Sequence
MITGKELRII SLLTLDTVFF LLEITIGYMS HSLALIADSF HMLNDIISLL VALWAVDVAK 60
NRGPDAKYTY GWKRAEILGA LINAVFLIAL CFSIMIEALQ RLIEPQEIQN PRLVLYVGVA 120
GLISNVVGLF LFHDHGSDSL HSHSHGSVES GNNDLDIESN ATHSHSHASL PNDNLAIDED 180
AISSPGPSGQ IGEVLPQSVV NRLSNESQPL LNHDDHDHSH ESKKPGHRSL NMHGVFLHVL 240
GDALGNIGVI AAALFIWKTE YSWRYYSDPI VSLIITIIIF SSALPLSRRA SRILLQATPS 300
TISADQIQRE ILAVPGVIAV HDFHVWNLTE SIYIASIHVQ IDCAPDKFMS SAKLIRKIFH 360
QHGIHSATVQ PEFVSGDVNE DIRRRFSIIA GGSPSSSQEA FDSHGNTEHG RKKRSPTAYG 420
ATTASSNCIV DDAVNCNTSN CL 442 
Gene Ontology
 GO:0000324; C:fungal-type vacuole; IDA:SGD.
 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
 GO:0005385; F:zinc ion transmembrane transporter activity; IMP:SGD.
 GO:0006882; P:cellular zinc ion homeostasis; IMP:SGD.
 GO:0006824; P:cobalt ion transport; NAS:SGD.
 GO:0006749; P:glutathione metabolic process; NAS:SGD.
 GO:0046686; P:response to cadmium ion; IEA:UniProtKB-KW. 
Interpro
 IPR002524; Cation_efflux.
 IPR027469; Cation_efflux_TMD. 
Pfam
 PF01545; Cation_efflux 
SMART
  
PROSITE
  
PRINTS