UniProt Accession

 DNJC5_HUMAN; Q9H3Z4; A8K0M0; B3KY68; E1P5G8; Q9H3Z5; Q9H7H2 

Genbank Protein ID

 AL118506; CH471077; CH471077; BC053642; AK024508; AK128776; AK289585 

Genbank Nucleotide ID

 CAC15495.1; EAW75191.1; EAW75192.1; AAH53642.1; BAB15798.1; BAG54730.1; BAF82274.1 

Protein Name

 DnaJ homolog subfamily C member 5 

Protein Synonyms/Alias

 Cysteine string protein; CSP 

Gene Name

 DNAJC5 

Gene Synonyms/Alias

 CSP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
41	SYRKLALKYHPDKNP	ubiquitination	[1, 2]
46	ALKYHPDKNPDNPEA	ubiquitination	[1]
56	DNPEAADKFKEINNA	acetylation	[3]
56	DNPEAADKFKEINNA	ubiquitination	[4, 5]
58	PEAADKFKEINNAHA	ubiquitination	[4, 5]
72	AILTDATKRNIYDKY	ubiquitination	[1, 2, 6, 7]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [6] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [7] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity). 

Sequence Annotation

 DOMAIN 13 82 J.
 MOD_RES 8 8 Phosphoserine.
 MOD_RES 10 10 Phosphoserine.
 MOD_RES 11 11 Phosphothreonine (By similarity).
 MOD_RES 12 12 Phosphoserine (By similarity).
 MOD_RES 15 15 Phosphoserine.
 MOD_RES 17 17 Phosphotyrosine (By similarity).
 MOD_RES 56 56 N6-acetyllysine.  

Keyword

 Acetylation; Alternative splicing; Cell membrane; Chaperone; Complete proteome; Disease mutation; Lipoprotein; Membrane; Neurodegeneration; Neuronal ceroid lipofuscinosis; Palmitate; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 198 AA 

Protein Sequence

Gene Ontology

 GO:0061202; C:clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane; TAS:Reactome.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0008021; C:synaptic vesicle; IEA:Compara.
 GO:0008219; P:cell death; IEA:UniProtKB-KW.
 GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Compara.
 GO:0007269; P:neurotransmitter secretion; TAS:Reactome. 

Interpro

 IPR001623; DnaJ_domain.
 IPR018253; DnaJ_domain_CS. 

Pfam

 PF00226; DnaJ 

SMART

 SM00271; DnaJ 

PROSITE

 PS00636; DNAJ_1
 PS50076; DNAJ_2 

PRINTS

 PR00625; JDOMAIN.