| Tag | Content |
|---|
| CPLM ID | CPLM-015647 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Histone-binding protein RBBP7 |
Protein Synonyms/Alias | Nucleosome-remodeling factor subunit RBAP46; Retinoblastoma-binding protein 7; RBBP-7 |
Gene Name | Rbbp7 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 4 | ****MASKEMFEDTV | acetylation | [1] | | 119 | GKIECEIKINHEGEV | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex (By similarity). |
Sequence Annotation | REPEAT 47 122 WD 1.
REPEAT 128 173 WD 2.
REPEAT 181 217 WD 3.
REPEAT 228 269 WD 4.
REPEAT 275 312 WD 5.
REPEAT 318 369 WD 6.
REPEAT 376 403 WD 7.
MOD_RES 2 2 N-acetylalanine (By similarity).
MOD_RES 3 3 Phosphoserine (By similarity).
MOD_RES 4 4 N6-acetyllysine; alternate (By
MOD_RES 99 99 Phosphoserine (By similarity).
MOD_RES 354 354 Phosphoserine (By similarity).
CROSSLNK 4 4 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | Acetylation; Chaperone; Chromatin regulator; Complete proteome; DNA replication; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Ubl conjugation; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 425 AA |
Protein Sequence | MASKEMFEDT VEERVINEEY KIWKKNTPFL YDLVMTHALQ WPSLTVQWLP EVTKPEGKDY 60
ALHWLVLGTH TSDEQNHLVV ARVHIPNDDA QFDASHCDSD KGEFGGFGSV TGKIECEIKI 120
NHEGEVNRAR YMPQNPHIIA TKTPSSDVLV FDYTKHPAKP DPSGECNPDL RLRGHQKEGY 180
GLSWNSNLSG HLLSASDDHT VCLWDINAGP KEGKIVDAKA IFTGHSAVVE DVAWHLLHES 240
LFGSVADDQK LMIWDTRSNT TSKPSHLVDA HTAEVNCLSF NPYSEFILAT GSADKTVALW 300
DLRNLKLKLH TFESHKDEIF QVHWSPHNET ILASSGTDRR LNVWDLSKIG EEQSAEDAED 360
GPPELLFIHG GHTAKISDFS WNPNEPWVIC SVSEDNIMQI WQMAENIYND EESDVTTSEL 420
EGQGS 425 |
Gene Ontology | GO:0035098; C:ESC/E(Z) complex; ISS:UniProtKB. GO:0016581; C:NuRD complex; ISS:UniProtKB. GO:0070370; P:cellular heat acclimation; ISS:UniProtKB. GO:0016568; P:chromatin modification; IEA:UniProtKB-KW. GO:0006260; P:DNA replication; IEA:UniProtKB-KW. GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB. GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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Pfam | |
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PRINTS | |