CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035822
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Guanine nucleotide binding protein, alpha q polypeptide, isoform CRA_a 
Protein Synonyms/Alias
 Guanine nucleotide-binding protein G(q) subunit alpha 
Gene Name
 Gnaq 
Gene Synonyms/Alias
 rCG_47814 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
102DTLKIPYKYEHNKAHacetylation[1]
102DTLKIPYKYEHNKAHubiquitination[2]
120VREVDVEKVSAFENPacetylation[1]
158YQLSDSTKYYLNDLDubiquitination[2]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; GTP-binding; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 359 AA 
Protein Sequence
MTLESIMACC LSEEAKEARR INDEIERQLR RDKRDARREL KLLLLGTGES GKSTFIKQMR 60
IIHGSGYSDE DKRGFTKLVY QNIFTAMQAM IRAMDTLKIP YKYEHNKAHA QLVREVDVEK 120
VSAFENPYVD AIKSLWNDPG IQECYDRRRE YQLSDSTKYY LNDLDRVADP SYLPTQQDVL 180
RVRVPTTGII EYPFDLQSVI FRMVDVGGQR SERRKWIHCF ENVTSIMFLV ALSEYDQVLV 240
ESDNENRMEE SKALFRTIIT YPWFQNSSVI LFLNKKDLLE EKIMYSHLVD YFPEYDGPQR 300
DAQAAREFIL KMFVDLNPDS DKIIYSHFTC ATDTENIRFV FAAVKDTILQ LNLKEYNLV 359 
Gene Ontology
 GO:0016020; C:membrane; IEA:Compara.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0005096; F:GTPase activator activity; IEA:Compara.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0004871; F:signal transducer activity; IEA:InterPro.
 GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; IEA:Compara.
 GO:0007610; P:behavior; IEA:Compara.
 GO:0048066; P:developmental pigmentation; IEA:Compara.
 GO:0042733; P:embryonic digit morphogenesis; IEA:Compara.
 GO:0021884; P:forebrain neuron development; IEA:Compara.
 GO:0007215; P:glutamate receptor signaling pathway; IEA:Compara.
 GO:0007507; P:heart development; IEA:Compara.
 GO:0006469; P:negative regulation of protein kinase activity; IEA:Compara.
 GO:0016322; P:neuron remodeling; IEA:Compara.
 GO:0060158; P:phospholipase C-activating dopamine receptor signaling pathway; IEA:Compara.
 GO:0009791; P:post-embryonic development; IEA:Compara.
 GO:0050821; P:protein stabilization; IEA:Compara.
 GO:0001508; P:regulation of action potential; IEA:Compara.
 GO:0035412; P:regulation of catenin import into nucleus; IEA:Compara.
 GO:0045634; P:regulation of melanocyte differentiation; IEA:Compara.
 GO:0001501; P:skeletal system development; IEA:Compara. 
Interpro
 IPR000654; Gprotein_alpha_Q.
 IPR001019; Gprotein_alpha_su.
 IPR011025; GproteinA_insert.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00503; G-alpha 
SMART
 SM00275; G_alpha 
PROSITE
  
PRINTS
 PR00318; GPROTEINA.
 PR00442; GPROTEINAQ.