CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002360
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cystathionine beta-lyase MetC 
Protein Synonyms/Alias
 CBL; Beta-cystathionase; Cysteine lyase 
Gene Name
 metC 
Gene Synonyms/Alias
 b3008; JW2975 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
17LVNAGRSKKYTLGAVacetylation[1]
42VFDSVEAKKHATRNRacetylation[1]
43FDSVEAKKHATRNRAacetylation[1]
142LIGADIVKHLQPNTKacetylation[1]
272QHHESSLKVAEWLAEacetylation[1]
301SKGHEFWKRDFTGSSacetylation[1]
316GLFSFVLKKKLNNEEacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
  
Sequence Annotation
 MOD_RES 210 210 N6-(pyridoxal phosphate)lysine.  
Keyword
 3D-structure; Amino-acid biosynthesis; Complete proteome; Cytoplasm; Direct protein sequencing; Lyase; Methionine biosynthesis; Pyridoxal phosphate; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 395 AA 
Protein Sequence
MADKKLDTQL VNAGRSKKYT LGAVNSVIQR ASSLVFDSVE AKKHATRNRA NGELFYGRRG 60
TLTHFSLQQA MCELEGGAGC VLFPCGAAAV ANSILAFIEQ GDHVLMTNTA YEPSQDFCSK 120
ILSKLGVTTS WFDPLIGADI VKHLQPNTKI VFLESPGSIT MEVHDVPAIV AAVRSVVPDA 180
IIMIDNTWAA GVLFKALDFG IDVSIQAATK YLVGHSDAMI GTAVCNARCW EQLRENAYLM 240
GQMVDADTAY ITSRGLRTLG VRLRQHHESS LKVAEWLAEH PQVARVNHPA LPGSKGHEFW 300
KRDFTGSSGL FSFVLKKKLN NEELANYLDN FSLFSMAYSW GGYESLILAN QPEHIAAIRP 360
QGEIDFSGTL IRLHIGLEDV DDLIADLDAG FARIV 395 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004121; F:cystathionine beta-lyase activity; IDA:EcoCyc.
 GO:0080146; F:L-cysteine desulfhydrase activity; IMP:EcoCyc.
 GO:0030170; F:pyridoxal phosphate binding; IDA:EcoCyc.
 GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW. 
Interpro
 IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
 IPR006233; Cys_b_lyase_bac.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2. 
Pfam
 PF01053; Cys_Met_Meta_PP 
SMART
  
PROSITE
 PS00868; CYS_MET_METAB_PP 
PRINTS