| Tag | Content |
|---|
| CPLM ID | CPLM-010407 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Eukaryotic translation initiation factor 4 gamma 2 |
Protein Synonyms/Alias | eIF-4-gamma 2; eIF-4G 2; eIF4G 2; Death-associated protein 5; DAP-5; p97 |
Gene Name | EIF4G2 |
Gene Synonyms/Alias | DAP5; OK/SW-cl.75 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 158 | AEGQPGQKQSTTFRR | ubiquitination | [1] | | 170 | FRRLLISKLQDEFEN | ubiquitination | [1] | | 187 | RNVDVYDKRENPLLP | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. |
Sequence Annotation | DOMAIN 78 308 MIF4G.
DOMAIN 543 666 MI.
DOMAIN 720 904 W2.
MOD_RES 1 1 N-acetylmethionine.
MOD_RES 395 395 Phosphoserine.
MOD_RES 508 508 Phosphothreonine.
MOD_RES 514 514 Phosphothreonine.
MOD_RES 902 902 Phosphoserine. |
Keyword | 3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Initiation factor; Phosphoprotein; Polymorphism; Protein biosynthesis; Reference proteome; Repressor; Translation regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 907 AA |
Protein Sequence | MESAIAEGGA SRFSASSGGG GSRGAPQHYP KTAGNSEFLG KTPGQNAQKW IPARSTRRDD 60
NSAANNSANE KERHDAIFRK VRGILNKLTP EKFDKLCLEL LNVGVESKLI LKGVILLIVD 120
KALEEPKYSS LYAQLCLRLA EDAPNFDGPA AEGQPGQKQS TTFRRLLISK LQDEFENRTR 180
NVDVYDKREN PLLPEEEEQR AIAKIKMLGN IKFIGELGKL DLIHESILHK CIKTLLEKKK 240
RVQLKDMGED LECLCQIMRT VGPRLDHERA KSLMDQYFAR MCSLMLSKEL PARIRFLLQD 300
TVELREHHWV PRKAFLDNGP KTINQIRQDA VKDLGVFIPA PMAQGMRSDF FLEGPFMPPR 360
MKMDRDPLGG LADMFGQMPG SGIGTGPGVI QDRFSPTMGR HRSNQLFNGH GGHIMPPTQS 420
QFGEMGGKFM KSQISLRPAQ SFLMNKNQVP KLQPQITMIP PSAQPPRTQT PPLGQTPQLG 480
LKTNPPLIQE KPAKTSKKPP PSKEELLKLT ETVVTEYLNS GNANEAVNGV REMRAPKHFL 540
PEMLSKVIIL SLDRSDEDKE KASSLISLLK QEGIATSDNF MQAFLNVLDQ CPKLEVDIPL 600
VKSYLAQFAA RAIISELVSI SELAQPLESG THFPLFLLCL QQLAKLQDRE WLTELFQQSK 660
VNMQKMLPEI DQNKDRMLEI LEGKGLSFLF PLLKLEKELL KQIKLDPSPQ TIYKWIKDNI 720
SPKLHVDKGF VNILMTSFLQ YISSEVNPPS DETDSSSAPS KEQLEQEKQL LLSFKPVMQK 780
FLHDHVDLQV SALYALQVHC YNSNFPKGML LRFFVHFYDM EIIEEEAFLA WKEDITQEFP 840
GKGKALFQVN QWLTWLETAE EEESEEEAD 869 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0016281; C:eukaryotic translation initiation factor 4F complex; IDA:UniProtKB. GO:0003677; F:DNA binding; IEA:InterPro. GO:0003743; F:translation initiation factor activity; IDA:UniProtKB. GO:0007050; P:cell cycle arrest; TAS:ProtInc. GO:0008219; P:cell death; TAS:ProtInc. GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome. GO:0006446; P:regulation of translational initiation; IDA:UniProtKB. GO:0016070; P:RNA metabolic process; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |