UniProt Accession

 NARL_ECOLI; P0AF28; P10957 

Genbank Protein ID

 X13360; M24910; X14884; X69189; U00096; AP009048 

Genbank Nucleotide ID

 CAA31742.1; AAA24199.1; CAA33023.1; CAA48935.1; AAC74305.1; BAA36089.1 

Protein Name

 Nitrate/nitrite response regulator protein NarL 

Protein Synonyms/Alias

  

Gene Name

 narL 

Gene Synonyms/Alias

 frdR; b1221; JW1212 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
100	EDVVTALKRGADGYL	acetylation	[1]
109	GADGYLLKDMEPEDL	acetylation	[1]
165	PRERDILKLIAQGLP	acetylation	[1]
174	IAQGLPNKMIARRLD	acetylation	[1]
188	DITESTVKVHVKHML	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 This protein activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal transmitted by either the NarX or NarQ proteins. 

Sequence Annotation

 DOMAIN 8 124 Response regulatory.
 DOMAIN 149 214 HTH luxR-type.
 DNA_BIND 173 192 H-T-H motif (By similarity).
 MOD_RES 59 59 4-aspartylphosphate (By similarity).  

Keyword

 3D-structure; Activator; ATP-binding; Complete proteome; DNA-binding; Nitrate assimilation; Nucleotide-binding; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation; Two-component regulatory system. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 216 AA 

Protein Sequence

Gene Ontology

 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003677; F:DNA binding; IMP:EcoCyc.
 GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0035556; P:intracellular signal transduction; IEA:GOC.
 GO:0042128; P:nitrate assimilation; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IMP:EcoCyc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR011006; CheY-like_superfamily.
 IPR016032; Sig_transdc_resp-reg_C-effctor.
 IPR001789; Sig_transdc_resp-reg_receiver.
 IPR000792; Tscrpt_reg_LuxR_C.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00196; GerE
 PF00072; Response_reg 

SMART

 SM00421; HTH_LUXR
 SM00448; REC 

PROSITE

 PS00622; HTH_LUXR_1
 PS50043; HTH_LUXR_2
 PS50110; RESPONSE_REGULATORY 

PRINTS

 PR00038; HTHLUXR.