| Tag | Content |
|---|
| CPLM ID | CPLM-000634 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Catenin delta-2 |
Protein Synonyms/Alias | Neural plakophilin-related ARM-repeat protein; NPRAP; Neurojungin |
Gene Name | Ctnnd2 |
Gene Synonyms/Alias | Catnd2; Nprap |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 537 | PSIDSIQKDPREFGW | ubiquitination | [1] | | 700 | SPLQDDRKIQLHSSQ | ubiquitination | [1] | | 1029 | KHSPKVVKAASQVLN | ubiquitination | [1] | | 1132 | KGEHTSRKDTMTAQN | ubiquitination | [1] | | 1174 | VPQEPSRKDYETYQP | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. Functions as a transcriptional activator when bound to ZBTB33. |
Sequence Annotation | REPEAT 391 433 ARM 1.
REPEAT 537 576 ARM 2.
REPEAT 579 618 ARM 3.
REPEAT 623 663 ARM 4.
REPEAT 679 721 ARM 5.
REPEAT 725 770 ARM 6.
REPEAT 832 872 ARM 7.
REPEAT 904 943 ARM 8.
REPEAT 997 1040 ARM 9.
MOD_RES 32 32 Phosphoserine.
MOD_RES 264 264 Phosphoserine.
MOD_RES 273 273 Phosphoserine.
MOD_RES 412 412 Phosphoserine.
MOD_RES 471 471 Phosphoserine.
MOD_RES 513 513 Phosphotyrosine.
MOD_RES 531 531 Phosphoserine.
MOD_RES 534 534 Phosphoserine.
MOD_RES 1094 1094 Phosphoserine.
MOD_RES 1098 1098 Phosphoserine.
MOD_RES 1149 1149 Phosphoserine. |
Keyword | Alternative splicing; Cell adhesion; Cell junction; Coiled coil; Complete proteome; Developmental protein; Glycoprotein; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1247 AA |
Protein Sequence | MFARKQSGAA PFGAMPVPDQ PPSASEKNSS LSPGLNTSNG DGSETETTSA ILASVKEQEL 60
QFERLTRELE AERQIVASQL ERCKLGSETG SMSSISSAGE QFHWQTQDGQ KDIEDELTTG 120
LELVDSCIRS LQESGILDPQ DYSTSERPSL LSQSALQLNS KPEGSFQYPA SYHSNQTLAL 180
GDTAPSQLPA RSTQARAAGQ SFSQGTTGRA GHLAGSEPAP PPPPPREPFA PSLGSAFHLP 240
DAPPAAAALY YSSSTLPAPP RGGSPLTTTQ GGSPTKLQRG GSAPEGAAYA APRGSSPKQS 300
PSRLAKSYST SSPINIVVSS AGLSPIRVTS PPTVQSTISS SPIHQLSSTI GTYATLSPTK 360
RLVHASEQYS KHSQELYATA TLQRPGSLAA GSRASYSSQH GHLAPELRAL QSPEHHIDPI 420
YEDRVYQKPP MRSLSQSQGD PLPPAHTGTF RTSTAPSSPG VDSVPLQRTG SQHGPQNAAA 480
ATFQRASYAA GPASNYADPY RQLQYCASVD SPYSKSGPAL PPEGTLARSP SIDSIQKDPR 540
EFGWRDPELP EVIQMLQHQF PSVQSNAAAY LQHLCFGDNK IKAEIRRQGG IQLLVDLLDH 600
RMTEVHRSAC GALRNLVYGK ANDDNKIALK NCGGIPALVR LLRKTTDLEI RELVTGVLWN 660
LSSCDALKMP IIQDALAVLT NAVIIPHSGW ENSPLQDDRK IQLHSSQVLR NATGCLRNVS 720
SAGEEARRRM RECDGLTDAL LYVIQSALGS SEIDSKTVEN CVCILRNLSY RLAAETSQGQ 780
HMGTDELDGL LCGETNGKDT ESSGCWGKKK KKKKSQDQWD GVGPLPDCAE PPKGIQMLWH 840
PSIVKPYLTL LSECSNPDTL EGAAGALQNL AAGSWKGWAE DVAGMAYALR SLPEGAPCLP 900
QWSVYIRAAV RKEKGLPILV ELLRIDNDRV VCAVATALRN MALDVRNKEL IGKYAMRDLV 960
HRLPGGNNSN NSGSKAMSDD TVTAVCCTLH EVITKNMENA KALRDAGGIE KLVGISKSKG 1020
DKHSPKVVKA ASQVLNSMWQ YRDLRSLYKK DGWSQYHFVA SSSTIERDRQ RPYSSSRTPS 1080
ISPVRVSPNN RSASAPASPR EMISLKERKT DYESAGNNAT YHGTKGEHTS RKDTMTAQNT 1140
GVSTLYRNSY GAPAEDIKQN QVSTQPVPQE PSRKDYETYQ PFPNSTRNYD ESFFEDQVHH 1200
RPPASEYTMH LGLKSTGNYV DFYSAARPYS ELNYETSHYP ASPDSWV 1247 |
Gene Ontology | GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0007155; P:cell adhesion; IEA:UniProtKB-KW. GO:0007612; P:learning; IMP:MGI. GO:0001763; P:morphogenesis of a branching structure; IDA:MGI. GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. GO:0048167; P:regulation of synaptic plasticity; IMP:MGI. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |