UniProt Accession

 STX12_RAT; G3V7P1; O70319; O88385 

Genbank Protein ID

 AF035632; AF044581; CH473968 

Genbank Nucleotide ID

 AAC23484.1; AAC18967.1; EDL80653.1 

Protein Name

 Syntaxin-12 

Protein Synonyms/Alias

 Syntaxin-13 

Gene Name

 Stx12 

Gene Synonyms/Alias

 Stx13 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
44	SQATAQIKNLMSQLG	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 SNARE that acts to regulate protein transport between endosomes and the trans-Golgi network (By similarity). The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro). 

Sequence Annotation

 DOMAIN 178 240 t-SNARE coiled-coil homology.
 MOD_RES 139 139 Phosphoserine (By similarity).
 MOD_RES 142 142 Phosphoserine (By similarity).
 MOD_RES 218 218 Phosphoserine (By similarity).  

Keyword

 3D-structure; Coiled coil; Complete proteome; Endosome; Golgi apparatus; Membrane; Phosphoprotein; Protein transport; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 274 AA 

Protein Sequence

Gene Ontology

 GO:0031083; C:BLOC-1 complex; IEA:Compara.
 GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0045121; C:membrane raft; IEA:Compara.
 GO:0045335; C:phagocytic vesicle; IEA:Compara.
 GO:0031201; C:SNARE complex; ISS:UniProtKB.
 GO:0005484; F:SNAP receptor activity; IBA:RefGenome.
 GO:0000149; F:SNARE binding; IBA:RefGenome.
 GO:0033344; P:cholesterol efflux; IEA:Compara.
 GO:0006886; P:intracellular protein transport; IBA:RefGenome.
 GO:0050821; P:protein stabilization; IEA:Compara.
 GO:0016079; P:synaptic vesicle exocytosis; IBA:RefGenome. 

Interpro

 IPR006012; Syntaxin/epimorphin_CS.
 IPR006011; Syntaxin_N.
 IPR010989; t-SNARE.
 IPR000727; T_SNARE_dom. 

Pfam

 PF05739; SNARE
 PF00804; Syntaxin 

SMART

 SM00503; SynN
 SM00397; t_SNARE 

PROSITE

 PS00914; SYNTAXIN
 PS50192; T_SNARE 

PRINTS