UniProt Accession

 CD81_MOUSE; P35762; Q91V78 

Genbank Protein ID

 S45012; S44957; S44966; S45001; S45008; S45010; AJ251835; AK166521; AK170741; AC015800; CH466531; BC011433; X59047 

Genbank Nucleotide ID

 AAB19417.1; AAB19417.1; AAB19417.1; AAB19417.1; AAB19417.1; AAB19417.1; CAB94774.1; BAE38825.1; BAE41994.1; EDL18195.1; AAH11433.1 

Protein Name

 CD81 antigen 

Protein Synonyms/Alias

 26 kDa cell surface protein TAPA-1; Target of the antiproliferative antibody 1; CD81 

Gene Name

 Cd81 

Gene Synonyms/Alias

 Tapa1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
124	DQIAKDVKQFYDQAL	ubiquitination	[1]
144	DDDANNAKAVVKTFH	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 May play an important role in the regulation of lymphoma cell growth. May be involved in the acrosome reaction. 

Sequence Annotation

 DISULFID 156 190 By similarity.
 DISULFID 157 175 By similarity.  

Keyword

 Complete proteome; Direct protein sequencing; Disulfide bond; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 236 AA 

Protein Sequence

Gene Ontology

 GO:0001772; C:immunological synapse; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; ISS:UniProtKB.
 GO:0000187; P:activation of MAPK activity; ISS:UniProtKB.
 GO:0006661; P:phosphatidylinositol biosynthetic process; ISS:UniProtKB.
 GO:0043128; P:positive regulation of 1-phosphatidylinositol 4-kinase activity; ISS:UniProtKB.
 GO:0030890; P:positive regulation of B cell proliferation; TAS:UniProtKB.
 GO:0030307; P:positive regulation of cell growth; TAS:UniProtKB.
 GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISS:UniProtKB.
 GO:0008104; P:protein localization; ISS:UniProtKB. 

Interpro

 IPR000301; Tetraspanin.
 IPR018499; Tetraspanin/Peripherin.
 IPR018503; Tetraspanin_CS.
 IPR008952; Tetraspanin_EC2. 

Pfam

 PF00335; Tetraspannin 

SMART

  

PROSITE

 PS00421; TM4_1 

PRINTS

 PR00259; TMFOUR.