| Tag | Content |
|---|
| CPLM ID | CPLM-026041 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Inosine-5'-monophosphate dehydrogenase |
Protein Synonyms/Alias | IMP dehydrogenase; IMPD; IMPDH |
Gene Name | guaB |
Gene Synonyms/Alias | GK0009 |
Created Date | July 27, 2013 |
Organism | Geobacillus kaustophilus (strain HTA426) |
NCBI Taxa ID | 235909 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 215 | IEFPNSAKDAKGRLI | acetylation | [1] |
|
Reference | [1] Proteomic analysis of acetylation in thermophilic Geobacillus kaustophilus. Lee DW, Kim D, Lee YJ, Kim JA, Choi JY, Kang S, Pan JG. Proteomics. 2013 Aug;13(15):2278-82. [ PMID: 23696451] |
Functional Description | Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity). |
Sequence Annotation | DOMAIN 95 153 CBS 1 (By similarity).
DOMAIN 157 215 CBS 2 (By similarity).
NP_BIND 301 303 NAD (By similarity).
REGION 341 343 IMP binding (By similarity).
REGION 364 365 IMP binding (By similarity).
REGION 388 392 IMP binding (By similarity).
ACT_SITE 308 308 Thioimidate intermediate (By similarity).
METAL 303 303 Potassium; via carbonyl oxygen (By
METAL 305 305 Potassium; via carbonyl oxygen (By
METAL 308 308 Potassium; via carbonyl oxygen (By
METAL 470 470 Potassium; via carbonyl oxygen; shared
METAL 471 471 Potassium; via carbonyl oxygen; shared
METAL 472 472 Potassium; via carbonyl oxygen; shared
BINDING 251 251 NAD (By similarity).
BINDING 306 306 IMP (By similarity).
BINDING 416 416 IMP (By similarity). |
Keyword | CBS domain; Complete proteome; GMP biosynthesis; Metal-binding; NAD; Oxidoreductase; Potassium; Purine biosynthesis; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 488 AA |
Protein Sequence | MWEAKFAKEG LTFDDVLLIP AKSDVLPRDV DVTTKLSDTL QLNIPILSAG MDTVTEAEMA 60
IAMARQGGLG IIHKNMSIEQ QAEQVDKVKR SERGVITDPF FLTPDHQVYD AEHLMSKYRI 120
SGVPIVNNPE EQKLVGIITN RDLRFIQDYS IKISEVMTKE NLITAPVGTT LEEAEKILQR 180
HKVEKLPLVD ENGVLKGLIT IKDIEKVIEF PNSAKDAKGR LIVGAAVGVT ADTMIRVKKL 240
VEAGVDVIVV DTAHGHSKGV LETVANIRRQ YPDLNIIAGN VATAEGTRDL IEAGANIIKV 300
GIGPGSICTT RVVAGVGVPQ ITAIYDCATE ARKHGVPIIA DGGIKYSGDI VKAIAAGAHA 360
VMLGSLLAGV SESPGETEIY QGRRFKVYRG MGSVAAMERG SKDRYFQEDA KKFVPEGIEG 420
RVPYKGPLAD TIYQLVGGLR AGMGYCGTRN LEELREKTQF IRMTSAGLRE SHPHDVQITK 480
EAPNYSAF 488 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |