| Tag | Content |
|---|
| CPLM ID | CPLM-016520 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Signal recognition particle subunit SRP68 |
Protein Synonyms/Alias | SRP68; Signal recognition particle 68 kDa protein |
Gene Name | Srp68 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 141 | WSYAMQLKQEANTEP | ubiquitination | [1] | | 276 | TEGLLAEKLEALITQ | ubiquitination | [1] | | 305 | RGRTVPVKIDKVRIF | ubiquitination | [1] | | 503 | SSHGGASKNSLKDLP | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function (By similarity). |
Sequence Annotation | MOD_RES 47 47 Phosphoserine (By similarity).
MOD_RES 240 240 Phosphoserine (By similarity).
MOD_RES 451 451 N6-acetyllysine (By similarity).
MOD_RES 616 616 Phosphotyrosine (By similarity).
MOD_RES 625 625 Phosphoserine (By similarity). |
Keyword | Acetylation; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Ribonucleoprotein; RNA-binding; Signal recognition particle. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 625 AA |
Protein Sequence | MAAEKQIPGG GSGGGGSGSG GGGGGSGGGR SAGGDENKEN ERPSAGSKAN KEFGDSLSLE 60
ILQIIKESQQ QHGLRHGDFQ RYRGYCSRRQ RRLRKTLNFK MGNRHKFTGK KVTEELLTDN 120
RYLLLVLMDA ERAWSYAMQL KQEANTEPRK RFHLLSRLRK AVKHAEELER LCESNRVDAK 180
TKLEAQAYTA YLSGMLRFEH QEWKSAIEAF NKCKTIYEKL ASAFTEEQAV LYNQRVEEIS 240
PNIRYCAYNI GDQSAINELM QMRLRSGGTE GLLAEKLEAL ITQTRAKQAA TMSEVEWRGR 300
TVPVKIDKVR IFLLGLADNE AAIVQAESEE TKERLFESML SECRDALQAV REELKPDQKQ 360
RDYALDGESG KVSNLQYLHS YLTYIKLSTA IRRNENMAKG LHRALLQQQP EDDSKRSPRP 420
QDLIRLYDII LQNLVELLQL PGLEEDRTFQ KEISLKTLVF KAYRCFFIAQ SYVLVKKWSE 480
ALVLYDRVLK YANEVSSHGG ASKNSLKDLP DVQELITQVR SEKCSLQAAA ILDANDSHQT 540
DTSSQVKDNT PLVERFESFC LDPSLVTKQA NLVHFPPGFQ PIPCKPLFFD LALNHVAFPP 600
LEDKLEQKTK SGLTGYIKGI FGFRS 625 |
Gene Ontology | GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell. GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; IEA:UniProtKB-KW. GO:0008312; F:7S RNA binding; IEA:InterPro. GO:0030942; F:endoplasmic reticulum signal peptide binding; IEA:InterPro. GO:0005047; F:signal recognition particle binding; IEA:InterPro. GO:0042493; P:response to drug; IEA:Compara. GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |