CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040212
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 AP-2 complex subunit alpha-1 
Protein Synonyms/Alias
  
Gene Name
 Ap2a1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
177TQLAVQTKRVAAQVDubiquitination[1]
247QDFFQRWKQLSLPLQubiquitination[1]
258LPLQEAQKIFKANHPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 317 AA 
Protein Sequence
XADLLGLRAA PPPAAPPAPV GGNLLVDVFS DGPTAQPSLG PTPEEAFLSP GPEDIGPPIP 60
EADELLNKFV CKNSGVLFEN QLLQIGVKSE FRQNLGVSWW PRGGIGVLGR GGVVGSIPWL 120
GWWQGMGSEE LGWSPHPPAA GRMYLFYGNK TSVQFQNFLP TVVHPGDLQT QLAVQTKRVA 180
AQVDGGAQVQ QVLNIECLRD FLTPPLLSVR FRYGGTAQSL TLKLPVTINK FFQPTEMAAQ 240
DFFQRWKQLS LPLQEAQKIF KANHPMDAEV TKAKLLGFGS ALLDNVDPNP ENFVGAGIIQ 300
TKALQVGCLL RLEPNAQ 317 
Gene Ontology
 GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
 GO:0030117; C:membrane coat; IDA:MGI.
 GO:0030141; C:secretory granule; TAS:MGI.
 GO:0006886; P:intracellular protein transport; TAS:MGI.
 GO:0016192; P:vesicle-mediated transport; TAS:MGI. 
Interpro
 IPR013038; Clathrin_a-adaptin_app_Ig-like.
 IPR003164; Clathrin_a-adaptin_app_sub_C.
 IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
 IPR015873; Clathrin_a/coatomer_app_sub_C.
 IPR009028; Coatomer/calthrin_app_sub_C.
 IPR013041; Coatomer/clathrin_app_Ig-like. 
Pfam
 PF02296; Alpha_adaptin_C
 PF02883; Alpha_adaptinC2 
SMART
 SM00809; Alpha_adaptinC2 
PROSITE
  
PRINTS