UniProt Accession

 PKP4_MOUSE; Q68FH0; A2AS46; Q640N0; Q68G56; Q8BK47; Q8BVH1; Q9CRE3 

Genbank Protein ID

 AL845536; BC078638; BC079848; BC082578; AK021168; AK077250; AK078240 

Genbank Nucleotide ID

 CAM20481.1; AAH78638.1; AAH79848.1; AAH82578.1; BAB32313.1; BAC36708.1; BAC37187.1 

Protein Name

 Plakophilin-4 

Protein Synonyms/Alias

 Armadillo-related protein 

Gene Name

 Pkp4 

Gene Synonyms/Alias

 Armrp 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
517	PSIDSIQKDPREFAW	ubiquitination	[1]
587	HRVLEVQKNACGALR	ubiquitination	[1]
600	LRNLVFGKSTDENKI	ubiquitination	[1]
680	SSFDDDHKIKFQTSL	ubiquitination	[1]
682	FDDDHKIKFQTSLVL	ubiquitination	[1]
773	ELDDLLGKESPSKDS	ubiquitination	[1]
910	RNKELIGKYAMRDLV	ubiquitination	[1]
963	ADSGGIEKLVNITKG	ubiquitination	[1]
1088	GLYPGSSKPSPIYIS	ubiquitination	[1]
1122	YQDDSTRKTLDAYRL	ubiquitination	[1]
1161	YSTQYGLKSTTNYVD	ubiquitination	[1]
1173	YVDFYSTKRPSYRAE	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques (By similarity). 

Sequence Annotation

 REPEAT 517 556 ARM 1.
 REPEAT 559 598 ARM 2.
 REPEAT 603 643 ARM 3.
 REPEAT 861 900 ARM 4.
 MOD_RES 132 132 Phosphoserine.
 MOD_RES 220 220 Phosphoserine.
 MOD_RES 225 225 Phosphothreonine.
 MOD_RES 230 230 Phosphoserine.
 MOD_RES 232 232 Phosphoserine.
 MOD_RES 272 272 Phosphoserine.
 MOD_RES 274 274 Phosphotyrosine.
 MOD_RES 280 280 Phosphoserine.
 MOD_RES 289 289 Phosphoserine.
 MOD_RES 313 313 Phosphoserine.
 MOD_RES 326 326 Phosphoserine (By similarity).
 MOD_RES 335 335 Phosphoserine.
 MOD_RES 336 336 Phosphoserine.
 MOD_RES 371 371 Phosphotyrosine.
 MOD_RES 402 402 Phosphoserine (By similarity).
 MOD_RES 405 405 Phosphoserine.
 MOD_RES 414 414 Phosphotyrosine (By similarity).
 MOD_RES 421 421 Phosphoserine.
 MOD_RES 446 446 Phosphoserine.
 MOD_RES 477 477 Phosphotyrosine.
 MOD_RES 509 509 Phosphoserine.
 MOD_RES 511 511 Phosphoserine.
 MOD_RES 514 514 Phosphoserine.
 MOD_RES 775 775 Phosphoserine (By similarity).
 MOD_RES 1047 1047 Phosphoserine.
 MOD_RES 1048 1048 Phosphoserine.
 MOD_RES 1133 1133 Phosphoserine.
 MOD_RES 1136 1136 Phosphoserine.
 CROSSLNK 610 610 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Alternative splicing; Cell adhesion; Cell junction; Cell membrane; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Isopeptide bond; Membrane; Phosphoprotein; Reference proteome; Repeat; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1190 AA 

Protein Sequence

Gene Ontology

 GO:0044291; C:cell-cell contact zone; IEA:Compara.
 GO:0030057; C:desmosome; ISS:UniProtKB.
 GO:0009898; C:internal side of plasma membrane; ISS:UniProtKB.
 GO:0030496; C:midbody; ISS:UniProtKB.
 GO:0072686; C:mitotic spindle; ISS:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
 GO:0051233; C:spindle midzone; ISS:UniProtKB.
 GO:0000922; C:spindle pole; ISS:UniProtKB.
 GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
 GO:0007043; P:cell-cell junction assembly; IMP:UniProtKB.
 GO:0032467; P:positive regulation of cytokinesis; ISS:UniProtKB.
 GO:0010628; P:positive regulation of gene expression; IMP:UniProtKB.
 GO:0032321; P:positive regulation of Rho GTPase activity; ISS:UniProtKB. 

Interpro

 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR000225; Armadillo. 

Pfam

 PF00514; Arm 

SMART

 SM00185; ARM 

PROSITE

 PS50176; ARM_REPEAT 

PRINTS