UniProt Accession

 HPPD_MOUSE; P49429; P97322; Q3UEQ0; Q91WV9 

Genbank Protein ID

 D29987; AK149416; BC013343; X59530 

Genbank Nucleotide ID

 BAA06267.1; BAE28861.1; AAH13343.1; CAA42111.1 

Protein Name

 4-hydroxyphenylpyruvate dioxygenase 

Protein Synonyms/Alias

 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; HPD; HPPDase; F Alloantigen; F protein 

Gene Name

 Hpd 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
7	*MTTYNNKGPKPERG	ubiquitination	[1]
10	TYNNKGPKPERGRFL	ubiquitination	[1]
39	AASFYCNKMGFEPLA	ubiquitination	[1]
63	EVVSHVIKQGKIVFV	ubiquitination	[1]
80	SALNPWNKEMGDHLV	ubiquitination	[1]
88	EMGDHLVKHGDGVKD	ubiquitination	[1]
94	VKHGDGVKDIAFEVE	ubiquitination	[1]
109	DCDHIVQKARERGAK	acetylation	[2]
109	DCDHIVQKARERGAK	ubiquitination	[1]
116	KARERGAKIVREPWV	ubiquitination	[1]
127	EPWVEQDKFGKVKFA	acetylation	[2]
127	EPWVEQDKFGKVKFA	ubiquitination	[1]
130	VEQDKFGKVKFAVLQ	ubiquitination	[1]
132	QDKFGKVKFAVLQTY	ubiquitination	[1]
149	TTHTLVEKINYTGRF	ubiquitination	[1]
166	GFEAPTYKDTLLPKL	ubiquitination	[1]
172	YKDTLLPKLPRCNLE	ubiquitination	[1]
237	TNYEESIKMPINEPA	ubiquitination	[1]
248	NEPAPGRKKSQIQEY	ubiquitination	[1]
249	EPAPGRKKSQIQEYV	ubiquitination	[1]
270	GVQHIALKTEDIITA	ubiquitination	[1]
297	AAPSSYYKLLRENLK	ubiquitination	[1]
304	KLLRENLKSAKIQVK	ubiquitination	[1]
369	GNFNSLFKAFEEEQA	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Key enzyme in the degradation of tyrosine (By similarity). 

Sequence Annotation

 METAL 183 183 Iron (By similarity).
 METAL 266 266 Iron (By similarity).
 METAL 349 349 Iron (By similarity).
 MOD_RES 2 2 N-acetylthreonine (By similarity).
 MOD_RES 250 250 Phosphoserine.  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Dioxygenase; Iron; Membrane; Metal-binding; Oxidoreductase; Phenylalanine catabolism; Phosphoprotein; Polymorphism; Reference proteome; Tyrosine catabolism. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 393 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:Compara.
 GO:0000139; C:Golgi membrane; IEA:Compara.
 GO:0003868; F:4-hydroxyphenylpyruvate dioxygenase activity; ISS:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006559; P:L-phenylalanine catabolic process; IEA:UniProtKB-UniPathway.
 GO:0006572; P:tyrosine catabolic process; ISS:UniProtKB. 

Interpro

 IPR005956; 4OHPhenylPyrv_dOase.
 IPR004360; Glyas_Fos-R_dOase_dom. 

Pfam

 PF00903; Glyoxalase 

SMART

  

PROSITE

  

PRINTS