UniProt Accession

 LFG2_MOUSE; Q8K097; Q3TY22; Q8K1F6; Q9D6K4 

Genbank Protein ID

 AF468028; AK013476; AK030513; AK129246; AK158960; BC032278 

Genbank Nucleotide ID

 AAM46781.1; BAB28874.1; BAC26999.1; BAC98056.1; BAE34742.1; AAH32278.1 

Protein Name

 Protein lifeguard 2 

Protein Synonyms/Alias

 Fas apoptotic inhibitory molecule 2; Neural membrane protein 35 

Gene Name

 Faim2 

Gene Synonyms/Alias

 Kiaa0950; Lfg; Lfg2; Nmp35 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
5	***MTQGKLSVANKA	ubiquitination	[1]
11	GKLSVANKAPGTEGQ	ubiquitination	[1]
26	QHQANGEKKDAPAVP	ubiquitination	[1]
27	HQANGEKKDAPAVPS	ubiquitination	[1]
49	ATSGEGLKAGTFPQG	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. Plays a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development. 

Sequence Annotation

 MOD_RES 39 39 Phosphotyrosine.
 CARBOHYD 192 192 N-linked (GlcNAc...) (Potential).  

Keyword

 Alternative splicing; Apoptosis; Cell junction; Cell membrane; Complete proteome; Glycoprotein; Membrane; Phosphoprotein; Postsynaptic cell membrane; Reference proteome; Synapse; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 317 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0045121; C:membrane raft; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0021681; P:cerebellar granular layer development; IMP:UniProtKB.
 GO:0021702; P:cerebellar Purkinje cell differentiation; IMP:UniProtKB.
 GO:0043523; P:regulation of neuron apoptotic process; IMP:UniProtKB. 

Interpro

 IPR006214; Bax_inhibitor_1-related. 

Pfam

 PF01027; Bax1-I 

SMART

  

PROSITE

  

PRINTS