CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016307
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 761 
Protein Synonyms/Alias
  
Gene Name
 ZNF761 
Gene Synonyms/Alias
 KIAA2033 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
445YKCNECGKTFSRTSSubiquitination[1]
566FNQQLTLKRHRRLHSubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
 May be involved in transcriptional regulation (By similarity). 
Sequence Annotation
 DOMAIN 8 81 KRAB.
 ZN_FING 215 237 C2H2-type 1; degenerate.
 ZN_FING 242 264 C2H2-type 2.
 ZN_FING 270 292 C2H2-type 3.
 ZN_FING 298 320 C2H2-type 4.
 ZN_FING 326 348 C2H2-type 5.
 ZN_FING 354 376 C2H2-type 6.
 ZN_FING 382 404 C2H2-type 7.
 ZN_FING 410 432 C2H2-type 8.
 ZN_FING 438 460 C2H2-type 9.
 ZN_FING 466 488 C2H2-type 10.
 ZN_FING 494 516 C2H2-type 11.
 ZN_FING 522 544 C2H2-type 12.
 ZN_FING 550 572 C2H2-type 13.
 ZN_FING 578 600 C2H2-type 14; degenerate.
 ZN_FING 606 628 C2H2-type 15.
 ZN_FING 634 656 C2H2-type 16.
 ZN_FING 662 684 C2H2-type 17.
 ZN_FING 690 712 C2H2-type 18.
 ZN_FING 718 740 C2H2-type 19.  
Keyword
 Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 746 AA 
Protein Sequence
MAFSQGLLTF RDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLDIS SKCTMKEFLS 60
TAQGNREVFH AGTLQIHESH HNGDFCYQDV DKDIHDYEFQ WQEDERNGHE APMTKIKKLT 120
GSTERYDQSH ARNKPIKDQL GSSFHSHLPE MHIFQTEEKI DNQVVKSIHD ASLVSTAQRI 180
SCRPKTHISN NHGNNFWNSS LLTQKQEVHM REKSFQCNES GKAFNYSSLL RKHQIIHLAD 240
KYKCDVCGKL FNQKRNLACH RRCHTGENPY KCNECGKTFS QTSSLTCHRR LHTGEKPYKC 300
EECDKAFHFK SILERHRIIH TEEKPYKCNE CGKTFRQKSI LTRHHRLHTG EKPYKCNECG 360
KTFSHKSSLT CHHRLHTGEK PYKCNECGKT FSHKSSLTCH RRLHTGEKPY KCEECDKAYS 420
FRSNFEIHRK IHTEDNAYKC NECGKTFSRT SSLTCHRRRH TGEQPYKCEE CDKAFRFKSN 480
LERHRRIHTG EKPYKCNECG KTFSRKSYLT CHHRLHTGEK AYKCNECSKT FSWKSSLTCH 540
RRLHSGEKPY KCKECGKTFN QQLTLKRHRR LHSGENPYKC EDSDKAYSFK SNLEIHQKIH 600
TEQNPYKCNE CGKTFSRTSS LTCHRRLHTG EKPYKCEECD KAFRVKSNLE GHRRIHTGEK 660
PYKCNECGKT FSRKSYFVCH HRLHTGEKPY KCNECGKNFS QKSSLICHHR LHTGEKPYKC 720
NECGKTFSQK SNLTCHRRLH TGEKQV 746 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001909; Krueppel-associated_box.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF01352; KRAB 
SMART
 SM00349; KRAB
 SM00355; ZnF_C2H2 
PROSITE
 PS50805; KRAB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS