UniProt Accession

 S35F6_HUMAN; Q8N357; D6W543; Q53GK2; Q8NBX6; Q9NWX0 

Genbank Protein ID

 AY358820; AK000562; AK075164; CR457243; AK222929; AC011740; CH471053; CH471053; BC028081 

Genbank Nucleotide ID

 AAQ89179.1; BAA91255.1; BAC11445.1; CAG33524.1; BAD96649.1; AAX93265.1; EAX00673.1; EAX00676.1; AAH28081.1 

Protein Name

 Solute carrier family 35 member F6 

Protein Synonyms/Alias

 ANT2-binding protein; ANT2BP; Transport and Golgi organization 9 homolog 

Gene Name

 SLC35F6 

Gene Synonyms/Alias

 C2orf18; UNQ3047/PRO9863 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
203	LEEKFVYKHNVHPLR	ubiquitination	[1, 2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter. 

Sequence Annotation

 DOMAIN 104 160 EamA.
 MOD_RES 365 365 Phosphothreonine.
 CARBOHYD 110 110 N-linked (GlcNAc...) (Potential).  

Keyword

 Complete proteome; Glycoprotein; Lysosome; Membrane; Mitochondrion; Phosphoprotein; Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 371 AA 

Protein Sequence

Gene Ontology

 GO:0005794; C:Golgi apparatus; IDA:HPA.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005765; C:lysosomal membrane; IDA:UniProtKB.
 GO:0005739; C:mitochondrion; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:1901029; P:negative regulation of mitochondrial outer membrane permeabilization; IMP:UniProtKB.
 GO:0008284; P:positive regulation of cell proliferation; IMP:UniProtKB.
 GO:0006810; P:transport; IEA:UniProtKB-KW. 

Interpro

 IPR009262; DUF914_euk.
 IPR012404; UCP036436. 

Pfam

 PF06027; DUF914 

SMART

  

PROSITE

  

PRINTS