UniProt Accession

 SNC2_YEAST; P33328; D6W324 

Genbank Protein ID

 L16243; Z49821; Z75235; BK006948 

Genbank Nucleotide ID

 AAA19816.1; CAA89974.1; CAA99647.1; DAA11090.1 

Protein Name

 Synaptobrevin homolog 2 

Protein Synonyms/Alias

  

Gene Name

 SNC2 

Gene Synonyms/Alias

 YOR327C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
62	RLTSIEDKADNLAIS	ubiquitination	[1, 2, 3, 4, 5]
74	AISAQGFKRGANRVR	ubiquitination	[5]

Reference

 [1] A proteomics approach to understanding protein ubiquitination.
 Peng J, Schwartz D, Elias JE, Thoreen CC, Cheng D, Marsischky G, Roelofs J, Finley D, Gygi SP.
 Nat Biotechnol. 2003 Aug;21(8):921-6. [PMID: 12872131]
 [2] Computational identification of ubiquitylation sites from protein sequences.
 Tung CW, Ho SY.
 BMC Bioinformatics. 2008 Jul 15;9:310. [PMID: 18625080]
 [3] Identification, analysis, and prediction of protein ubiquitination sites.
 Radivojac P, Vacic V, Haynes C, Cocklin RR, Mohan A, Heyen JW, Goebl MG, Iakoucheva LM.
 Proteins. 2010 Feb 1;78(2):365-80. [PMID: 19722269]
 [4] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047]
 [5] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 SNC1 and SNC2 are vesicle-targeting proteins essential for normal secretory traffic between the Golgi and the plasma membrane. They may also be involved in vesicle fusion. 

Sequence Annotation

 DOMAIN 27 87 v-SNARE coiled-coil homology.
 MOD_RES 58 58 Phosphoserine.
 LIPID 94 94 S-palmitoyl cysteine (Probable).
 CROSSLNK 62 62 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Coiled coil; Complete proteome; Isopeptide bond; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 115 AA 

Protein Sequence

Gene Ontology

 GO:0005768; C:endosome; IDA:SGD.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031201; C:SNARE complex; IPI:SGD.
 GO:0005802; C:trans-Golgi network; IDA:SGD.
 GO:0030658; C:transport vesicle membrane; IDA:SGD.
 GO:0005484; F:SNAP receptor activity; IDA:SGD.
 GO:0006897; P:endocytosis; IGI:SGD.
 GO:0006887; P:exocytosis; IMP:SGD.
 GO:0006893; P:Golgi to plasma membrane transport; IMP:SGD.
 GO:0006906; P:vesicle fusion; IDA:SGD. 

Interpro

 IPR001388; Synaptobrevin.
 IPR016444; Synaptobrevin_met/fun. 

Pfam

 PF00957; Synaptobrevin 

SMART

  

PROSITE

 PS00417; SYNAPTOBREVIN
 PS50892; V_SNARE 

PRINTS

 PR00219; SYNAPTOBREVN.