CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038197
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Thioredoxin domain-containing protein 5 
Protein Synonyms/Alias
  
Gene Name
 Txndc5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
18TWNDLGDKYNSMEDAacetylation[1]
31DAKVYVAKVDCTADSacetylation[1]
53VRGYPTLKFFKPGQEubiquitination[2]
56YPTLKFFKPGQEAVKacetylation[1]
63KPGQEAVKYQGPRDFacetylation[1, 3]
63KPGQEAVKYQGPRDFubiquitination[2]
157SETVKIGKVDCTQHYacetylation[1]
242TVLALTEKSFEDTIAacetylation[1]
302AERNVCSKYSVRGYPacetylation[1]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Disulfide bond; Redox-active center; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 344 AA 
Protein Sequence
MCGHCQRLQP TWNDLGDKYN SMEDAKVYVA KVDCTADSDV CSAQGVRGYP TLKFFKPGQE 60
AVKYQGPRDF ETLENWMLQT LNEEPATPEP EAEPPRAPEL KQGLYELSAN NFELHVSQGN 120
HFIKFFAPWC GHCKALAPTW EQLALGLEHS ETVKIGKVDC TQHYAVCSEH QVRGYPTLLW 180
FRDGKKVDQY KGKRDLESLR DYVQSQLQGS EAAPETVEPS EAPVMAAEPT GDKGTVLALT 240
EKSFEDTIAQ GITFVKFYAP WCGHCKNLAP TWEELSKKEF PGLSDVTIAE VDCTAERNVC 300
SKYSVRGYPT LLLFRGGEKV GEHNGGRDLD SLHSFVLRQA KDEL 344 
Gene Ontology
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0016853; F:isomerase activity; IEA:InterPro.
 GO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro.
 GO:0006662; P:glycerol ether metabolic process; IEA:InterPro. 
Interpro
 IPR005788; Disulphide_isomerase.
 IPR005746; Thioredoxin.
 IPR012336; Thioredoxin-like_fold.
 IPR017937; Thioredoxin_CS.
 IPR013766; Thioredoxin_domain. 
Pfam
 PF00085; Thioredoxin 
SMART
  
PROSITE
 PS00194; THIOREDOXIN_1
 PS51352; THIOREDOXIN_2 
PRINTS
 PR00421; THIOREDOXIN.