CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024096
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 V-type proton ATPase 116 kDa subunit a isoform 1 
Protein Synonyms/Alias
 V-ATPase 116 kDa isoform a1; Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit; Vacuolar adenosine triphosphatase subunit Ac116; Vacuolar proton pump subunit 1; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1 
Gene Name
 Atp6v0a1 
Gene Synonyms/Alias
 Atp6n1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
50DVNVFQRKFVNEVRRubiquitination[1]
74FVEKEIRKANIPIMDubiquitination[1]
103DLEANFEKIENELKEubiquitination[1]
119NTNQEALKRNFLELTubiquitination[1]
242QLKNRVKKICEGFRAubiquitination[1]
262PETPQERKEMASGVNubiquitination[1]
295RVLQAAAKNIRVWFIubiquitination[1]
373QTPPTYNKTNKFTHGubiquitination[1]
674RHQYLRKKHLGTLNFubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). 
Sequence Annotation
 MOD_RES 257 257 Phosphothreonine.
 MOD_RES 371 371 Phosphotyrosine.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasmic vesicle; Direct protein sequencing; Hydrogen ion transport; Ion transport; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 839 AA 
Protein Sequence
MGELFRSEEM TLAQLFLQSE AAYCCVSELG ELGKVQFRDL NPDVNVFQRK FVNEVRRCEE 60
MDRKLRFVEK EIRKANIPIM DTGENPEVPF PRDMIDLEAN FEKIENELKE INTNQEALKR 120
NFLELTELKF ILRKTQQFFD EAELHHQQMA DPDLLEESSS LLEPNEMGRG APLRLGFVAG 180
VINRERIPTF ERMLWRVCRG NVFLRQAEIE NPLEDPVTGD YVHKSVFIIF FQGDQLKNRV 240
KKICEGFRAS LYPCPETPQE RKEMASGVNT RIDDLQMVLN QTEDHRQRVL QAAAKNIRVW 300
FIKVRKMKAI YHTLNLCNID VTQKCLIAEV WCPVTDLDSI QFALRRGTEH SGSTVPSILN 360
RMQTNQTPPT YNKTNKFTHG FQNIVDAYGI GTYREINPAP YTVITFPFLF AVMFGDFGHG 420
ILMTLFAVWM VLRESRILSQ KHENEMFSMV FSGRYIILLM GLFSIYTGLI YNDCFSKSLN 480
IFGSSWSVRP MFTQGNWTEE TLLGSSVLQL NPAIPGVFGG PYPFGIDPIW NIATNKLTFL 540
NSFKMKMSVI LGIIHMLFGV SLSLFNHIYF KKPLNIYFGF IPEIIFMSSL FGYLVILIFY 600
KWTAYDAHSS RNAPSLLIHF INMFLFSYPE SGNAMLYSGQ KGIQCFLIVV AMLCVPWMLL 660
FKPLILRHQY LRKKHLGTLN FGGIRVGNGP TEEDAEIIQH DQLSTHSEDA EEFDFGDTMV 720
HQAIHTIEYC LGCISNTASY LRLWALSLAH AQLSEVLWTM VIHIGLHVRS LAGGLGLFFI 780
FAAFATLTVA ILLIMEGLSA FLHALRLHWV EFQNKFYTGT GFKFLPFSFE HIREGKFDE 839 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
 GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
 GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro. 
Interpro
 IPR002490; V-ATPase_116kDa_su.
 IPR026028; V-type_ATPase_116kDa_su_euka. 
Pfam
 PF01496; V_ATPase_I 
SMART
  
PROSITE
  
PRINTS