CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042485
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Structural maintenance of chromosomes protein 1A 
Protein Synonyms/Alias
  
Gene Name
 SMC1A 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
151AVESIAMKNPKERTAubiquitination[1]
154SIAMKNPKERTALFEubiquitination[2]
175ELAQEYDKRKKEMVKubiquitination[2, 3, 4]
182KRKKEMVKAEEDTQFubiquitination[2, 5]
218ADRYQRLKDEVVRAQubiquitination[2, 4]
245VEIEKLNKELASKNKubiquitination[2]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 289 AA 
Protein Sequence
XWYTPTPFYS SLEAALLNFR PSAPVFRMLE VSIPTPHRYV RGKSNLMDAI SFVLGEKTSN 60
LRVKTLRDLI HGAPVGKPAA NRAFVSMVYS EEGAEDRTFA RVIVGGSSEY KINNKVVQLH 120
EYSEELEKLG ILIKARNFLV FQGAVESIAM KNPKERTALF EEISRSGELA QEYDKRKKEM 180
VKAEEDTQFN YHRKKNIAAE RKEAKQEKEE ADRYQRLKDE VVRAQVQLQL FKLYHNEVEI 240
EKLNKELASK NKEIEKDKKR MDKVEDELKE KKKELGKMMR EQQQIEKEI 289 
Gene Ontology
  
Interpro
 IPR027417; P-loop_NTPase.
 IPR003395; RecF/RecN/SMC. 
Pfam
 PF02463; SMC_N 
SMART
  
PROSITE
  
PRINTS