UniProt Accession

 GATA3_HUMAN; P23771; Q5VWG7; Q5VWG8; Q96J16 

Genbank Protein ID

 X58072; X55037; X55122; M69106; AY497006; AL390294; AL390294; CH471072; CH471072; BC003070; BC006793 

Genbank Nucleotide ID

 CAA41102.1; CAA38877.1; CAA38916.1; AAA35870.1; AAR32096.1; CAH73143.1; CAH73144.1; EAW86367.1; EAW86368.1; AAH03070.1; AAH06793.1 

Protein Name

 Trans-acting T-cell-specific transcription factor GATA-3 

Protein Synonyms/Alias

 GATA-binding factor 3 

Gene Name

 GATA3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
292	NACGLYHKMNGQNRP	acetylation	[1]
302	GQNRPLIKPKRRLSA	acetylation	[2]
304	NRPLIKPKRRLSAAR	acetylation	[1]
346	NACGLYYKLHNINRP	acetylation	[1]
371	RNRKMSSKSKKCKKV	acetylation	[3]

Reference

 [1] Acetylation of GATA-3 affects T-cell survival and homing to secondary lymphoid organs.
 Yamagata T, Mitani K, Oda H, Suzuki T, Honda H, Asai T, Maki K, Nakamoto T, Hirai H.
 EMBO J. 2000 Sep 1;19(17):4676-87. [PMID: 10970860]
 [2] Proteome-wide prediction of acetylation substrates.
 Basu A, Rose KL, Zhang J, Beavis RC, Ueberheide B, Garcia BA, Chait B, Zhao Y, Hunt DF, Segal E, Allis CD, Hake SB.
 Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13785-90. [PMID: 19666589]
 [3] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. 

Sequence Annotation

 ZN_FING 263 287 GATA-type 1.
 ZN_FING 317 341 GATA-type 2.
 MOD_RES 115 115 Phosphoserine.
 MOD_RES 162 162 Phosphoserine.  

Keyword

 3D-structure; Activator; Alternative splicing; Complete proteome; Deafness; Disease mutation; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 443 AA 

Protein Sequence

Gene Ontology

 GO:0000790; C:nuclear chromatin; IDA:BHF-UCL.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0000987; F:core promoter proximal region sequence-specific DNA binding; IDA:UniProtKB.
 GO:0001046; F:core promoter sequence-specific DNA binding; IDA:UniProtKB.
 GO:0070888; F:E-box binding; IDA:BHF-UCL.
 GO:0001158; F:enhancer sequence-specific DNA binding; IEA:Compara.
 GO:0001078; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; IMP:UniProtKB.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IEA:Compara.
 GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IEA:Compara.
 GO:0003713; F:transcription coactivator activity; IDA:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0003180; P:aortic valve morphogenesis; ISS:UniProtKB.
 GO:0007411; P:axon guidance; IEA:Compara.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0061290; P:canonical Wnt receptor signaling pathway involved in metanephric kidney development; ISS:UniProtKB.
 GO:0003215; P:cardiac right ventricle morphogenesis; ISS:UniProtKB.
 GO:0001709; P:cell fate determination; ISS:UniProtKB.
 GO:0048469; P:cell maturation; IEA:Compara.
 GO:0071773; P:cellular response to BMP stimulus; IEA:Compara.
 GO:0035457; P:cellular response to interferon-alpha; IEP:UniProtKB.
 GO:0071353; P:cellular response to interleukin-4; IEP:UniProtKB.
 GO:0071356; P:cellular response to tumor necrosis factor; IEP:UniProtKB.
 GO:0006952; P:defense response; TAS:ProtInc.
 GO:0048589; P:developmental growth; IEA:Compara.
 GO:0043583; P:ear development; IMP:UniProtKB.
 GO:0035162; P:embryonic hemopoiesis; IEA:Compara.
 GO:0030218; P:erythrocyte differentiation; IEA:Compara.
 GO:0006959; P:humoral immune response; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0042472; P:inner ear morphogenesis; IEA:Compara.
 GO:0072643; P:interferon-gamma secretion; IEA:Compara.
 GO:0072602; P:interleukin-4 secretion; IEA:Compara.
 GO:0002088; P:lens development in camera-type eye; IEA:Compara.
 GO:0072676; P:lymphocyte migration; IDA:UniProtKB.
 GO:0008584; P:male gonad development; ISS:UniProtKB.
 GO:0060374; P:mast cell differentiation; IEA:Compara.
 GO:0060231; P:mesenchymal to epithelial transition; IDA:UniProtKB.
 GO:0001823; P:mesonephros development; ISS:UniProtKB.
 GO:0045786; P:negative regulation of cell cycle; IMP:UniProtKB.
 GO:2000146; P:negative regulation of cell motility; IMP:UniProtKB.
 GO:2000607; P:negative regulation of cell proliferation involved in mesonephros development; ISS:UniProtKB.
 GO:2000352; P:negative regulation of endothelial cell apoptotic process; IMP:UniProtKB.
 GO:0045599; P:negative regulation of fat cell differentiation; IMP:UniProtKB.
 GO:2000703; P:negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation; ISS:UniProtKB.
 GO:2000734; P:negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation; ISS:UniProtKB.
 GO:0050728; P:negative regulation of inflammatory response; IMP:UniProtKB.
 GO:0032689; P:negative regulation of interferon-gamma production; IEA:Compara.
 GO:0032703; P:negative regulation of interleukin-2 production; IEA:Compara.
 GO:0033600; P:negative regulation of mammary gland epithelial cell proliferation; IDA:UniProtKB.
 GO:0072179; P:nephric duct formation; ISS:UniProtKB.
 GO:0001764; P:neuron migration; IEA:Compara.
 GO:0042421; P:norepinephrine biosynthetic process; ISS:UniProtKB.
 GO:0071599; P:otic vesicle development; IEA:Compara.
 GO:0060017; P:parathyroid gland development; IEA:Compara.
 GO:0035898; P:parathyroid hormone secretion; IEA:Compara.
 GO:0060037; P:pharyngeal system development; ISS:UniProtKB.
 GO:0014065; P:phosphatidylinositol 3-kinase cascade; ISS:UniProtKB.
 GO:0010595; P:positive regulation of endothelial cell migration; IMP:UniProtKB.
 GO:0032736; P:positive regulation of interleukin-13 production; IEA:Compara.
 GO:2000667; P:positive regulation of interleukin-13 secretion; IDA:UniProtKB.
 GO:0032753; P:positive regulation of interleukin-4 production; ISS:UniProtKB.
 GO:0032754; P:positive regulation of interleukin-5 production; IEA:Compara.
 GO:2000664; P:positive regulation of interleukin-5 secretion; IDA:UniProtKB.
 GO:0051897; P:positive regulation of protein kinase B signaling cascade; IMP:UniProtKB.
 GO:0045582; P:positive regulation of T cell differentiation; ISS:UniProtKB.
 GO:2000611; P:positive regulation of thyroid hormone generation; IMP:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:2000679; P:positive regulation of transcription regulatory region DNA binding; IMP:UniProtKB.
 GO:0072107; P:positive regulation of ureteric bud formation; ISS:UniProtKB.
 GO:0009791; P:post-embryonic development; IEA:Compara.
 GO:0002572; P:pro-T cell differentiation; IEA:Compara.
 GO:0043370; P:regulation of CD4-positive, alpha-beta T cell differentiation; IEA:Compara.
 GO:2000683; P:regulation of cellular response to X-ray; IMP:UniProtKB.
 GO:0042035; P:regulation of cytokine biosynthetic process; ISS:UniProtKB.
 GO:2000114; P:regulation of establishment of cell polarity; IEA:Compara.
 GO:0061085; P:regulation of histone H3-K27 methylation; IEA:Compara.
 GO:0051569; P:regulation of histone H3-K4 methylation; IEA:Compara.
 GO:0072182; P:regulation of nephron tubule epithelial cell differentiation; ISS:UniProtKB.
 GO:0043523; P:regulation of neuron apoptotic process; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0043627; P:response to estrogen stimulus; IEP:UniProtKB.
 GO:0045471; P:response to ethanol; IEA:Compara.
 GO:0010332; P:response to gamma radiation; IEA:Compara.
 GO:0009615; P:response to virus; IEP:UniProtKB.
 GO:0048485; P:sympathetic nervous system development; ISS:UniProtKB.
 GO:0050852; P:T cell receptor signaling pathway; ISS:UniProtKB.
 GO:0045064; P:T-helper 2 cell differentiation; IEA:Compara.
 GO:0045061; P:thymic T cell selection; IEA:Compara.
 GO:0048538; P:thymus development; IEA:Compara.
 GO:0031929; P:TOR signaling cascade; ISS:UniProtKB.
 GO:0001806; P:type IV hypersensitivity; IEA:Compara.
 GO:0035799; P:ureter maturation; IEA:Compara.
 GO:0060676; P:ureteric bud formation; ISS:UniProtKB.
 GO:0060065; P:uterus development; ISS:UniProtKB.
 GO:0003281; P:ventricular septum development; ISS:UniProtKB. 

Interpro

 IPR016374; TF_GATA-1/2/3.
 IPR000679; Znf_GATA.
 IPR013088; Znf_NHR/GATA. 

Pfam

 PF00320; GATA 

SMART

 SM00401; ZnF_GATA 

PROSITE

 PS00344; GATA_ZN_FINGER_1
 PS50114; GATA_ZN_FINGER_2 

PRINTS

 PR00619; GATAZNFINGER.